Inflammation is an essential mechanism of various diseases. The development and
resolution of inflammation are complex immune-modulation processes which induce the …

Pulmonary fibrotic diseases are characterized by proliferation of lung fibroblasts and
myofibroblasts and excessive deposition of extracellular matrix proteins. Depending on the …

Exposure to air pollution and other environmental inhalation hazards, such as occupational
exposures to dusts and fumes, aeroallergens, and tobacco smoke, is a significant cause of …

Formation of specialized pro-resolving lipid mediators (SPMs) such as lipoxins or resolvins
usually involves arachidonic acid 5-lipoxygenase (5-LO, ALOX5) and different types of …

Chronic inflammation is an underlying feature of many diseases, including chronic
obstructive pulmonary disease, rheumatoid arthritis, asthma, and multiple sclerosis. There is …

Bronchi are exposed daily to irritants, microbes and allergens as well as extremes of
temperature and acid. The airway mucosal epithelium plays a pivotal role as a sentinel …

Exposure to ozone (O3) induces lung injury, pulmonary inflammation, and alters lipid
metabolism. During tissue inflammation, specialized pro-resolving lipid mediators (SPMs) …

Lipid metabolism plays an important role in many lung functions. Disorders of lipid
metabolism are part of the pathogenesis of chronic obstructive pulmonary disease (COPD) …

Resolution of acute lung inflammation and injury is an active process; it is not merely the
absence of proinflammatory signals. Restoration of homeostasis is coordinated by specific …

A new genus of specialized pro-resolving mediators (SPM) which include several families of
distinct local mediators (lipoxins, resolvins, protectins, and maresins) are actively involved in …