Rationale: A significant population of patients with severe asthma and chronic obstructive
pulmonary disease is less responsive to β2-adrenoceptor agonists and corticosteroids, and …

PGE2 is an important cyclooxygenase product that modulates airway inflammatory and
smooth muscle responses. Signal transduction is mediated by four EP receptor subtypes …

Background Asthma and chronic obstructive pulmonary disease are airway inflammatory
diseases characterised by airflow obstruction. Currently approved bronchodilators such as …

Background and Purpose The guinea pig trachea (GPT) is commonly used in airway
pharmacology. The aim of this study was to define the expression and function of EP …

Prostaglandin E2 (PGE2) has complex effects on airway tone, and the existence of four
PGE2 [E-prostanoid (EP)] receptors, each with distinct signaling characteristics, has …

Prostaglandin D 2 (PGD 2) causes cough and levels are increased in asthma suggesting
that it may contribute to symptoms. Although the prostaglandin D 2 receptor 2 (DP 2) is a …

Substance P (SP) and ATP evoke transient, epithelium-dependent relaxation of constricted
mouse tracheal smooth muscle. Relaxation to either SP or ATP is blocked by indomethacin …

Background Inhaled prostaglandin (PG) E 2 might inhibit asthmatic responses, but the
mechanisms involved remain undefined. Objective We sought to characterize the direct and …

Increased airway smooth muscle mass due to cell proliferation contributes to airway hyper-
responsiveness and remodeling in patients with asthma. Prostaglandin E2 (PGE2) inhibits …

Prostaglandins have been shown to influence the sensitivity of the cough reflex. To
investigate putative mechanisms of this, we examined the effects of inhaled prostaglandins …