Alterations occur in the homeostasis of the transition metals iron (Fe2+) and copper (Cu2+)
during aging and these are further amplified in neurodegenerative diseases, including …

The origin and/or the evolution of brain diseases of high morbidity and mortality such as
cerebrovascular diseases, Alzheimer's Dementia or Parkinson's disease have been linked …

Like other organs, brain functions diminish with age. Furthermore, for a variety of
neurological disorders—including Alzheimer's disease—age is one of the higher-risk …

Alzheimer's disease (AD) is the most frequent age-associated disease with no treatments
that can prevent, delay, slow, or stop its progression. Thus, new approaches to drug …

Research demonstrates that antioxidants and metal chelators may be of beneficial use in the
treatment of neurodegenerative diseases, such as Alzheimer's disease (AD). This study …

Flavanones are a group of flavonoids that derive from their immediate chalcone precursors
through the action of chalcone isomerase enzymes. The Aromatic A and B rings, C4‐keto …

Dementia is a growing problem around the globe as the world's population continues to age.
Multiple studies have identified potentially modifiable risk factors for the development of …

It is becoming increasingly clear that neurological diseases are multi-factorial involving
disruptions in multiple cellular systems. Thus, while each disease has its own initiating …

Multiple factors have been implicated in the age-related declines in brain function. Thus, it is
unlikely that modulating only a single factor will be effective at slowing this decline. A better …

Many lines of evidence suggest that oxidative stress resulting in reactive oxygen species
(ROS) generation and inflammation play a pivotal role in the age-associated cognitive …