A large fraction of the mammalian genome is organized into inactive chromosomal domains
along the nuclear lamina. The mechanism by which these lamina associated domains …

In metazoan cell nuclei, hundreds of large chromatin domains are in close contact with the
nuclear lamina. Such lamina-associated domains (LADs) are thought to help organize …

Nuclear organization has been implicated in regulating gene activity. Recently, large
developmentally regulated regions of the genome dynamically associated with the nuclear …

The nuclear lamina (NL) interacts with hundreds of large genomic regions termed lamina
associated domains (LADs). The dynamics of these interactions and the relation to …

An increasing number of studies indicate that chromosomes are spatially organized in the
interphase nucleus and that some genes tend to occupy characteristic zones of the nuclear …

Background Association of chromatin with lamin proteins at the nuclear periphery has
emerged as a potential mechanism to coordinate cell type-specific gene expression and …

The nuclear lamina (NL) is a thin meshwork of filaments that lines the inner nuclear
membrane, thereby providing a platform for chromatin binding and supporting genome …

The nuclear lamina (NL) consists of a thin meshwork of lamins and associated proteins that
lines the inner nuclear membrane (INM). In metazoan nuclei, a large proportion of the …

At the nuclear periphery, associations of chromatin with the nuclear lamina through lamina-
associated domains (LADs) aid functional organization of the genome. We review the …

The peripheral nuclear lamina, which is largely but not entirely associated with inactive
chromatin, is considered to be an important determinant of nuclear structure and gene …