Establishment and assessment of pancreas preservation using oxygenated hypothermic machine perfusion

G Hakim - 2022 - ora.ox.ac.uk
Background: Pancreatic transplantation is the treatment of choice for a selected group of
patients with the most severe complications of diabetes. The two main causes of early failure …

[PDF][PDF] Prototype development of a system for hypothermic oxygenated perfusion of the pancreas

M Leemkuil, C Krikke, RA Pol - Strategies to improve outcome after …, 2022 - research.rug.nl
Worldwide about 422 million patients suffer from diabetes mellitus, of which 10% are
diagnosed with type 1 diabetes mellitus (T1DM), a prevalence that has doubled in the past …

Ischemia-reperfusion injuries assessment during pancreas preservation

T Prudhomme, JF Mulvey, LAJ Young… - International Journal of …, 2021 - mdpi.com
Maintaining organ viability between donation and transplantation is of critical importance for
optimal graft function and survival. To date in pancreas transplantation, static cold storage …

Hypothermic oxygenated machine perfusion of the human donor pancreas

M Leemkuil, G Lier, MA Engelse, RJ Ploeg… - Transplantation …, 2018 - journals.lww.com
Background Transplantation of beta cells by pancreas or islet transplantation is the
treatment of choice for a selected group of patients suffering from type 1 diabetes mellitus …

Machine Perfusion of the Pancreas: What Can We Learn from five Decades of Experimental Studies?

F Staderini, M Dimitri, N Navari, A Corvi… - JOURNAL OF …, 2023 - flore.unifi.it
Background: Pancreas transplantation is currently the best option for patients with severe
complications of diabetes. This organ is however particularly vulnerable to Ischemia …

Development of ex situ normothermic reperfusion as an innovative method to assess pancreases after preservation

AE Ogbemudia, G Hakim, F Dengu… - Transplant …, 2021 - Wiley Online Library
Static cold storage (SCS) is the standard method for pancreas preservation prior to
transplantation; however, it does not permit organ assessment. Normothermic reperfusion …

Machine perfusion and the pancreas: will it increase the donor pool?

K Hamaoui, V Papalois - Current Diabetes Reports, 2019 - Springer
Abstract Purpose of Review Pancreas transplantation enables complete patient
independence from exogenous insulin administration and increases both patient survival …

338.2: Oxygenated hypothermic machine perfusion of the pancreas; a porcine circulatory death model to compare a 'continuous' and an 'end-ischaemic'approach

MA Elzawahry, J Fallon, S Nawaz, B Hastoy… - …, 2023 - journals.lww.com
Methods: Porcine pancreases were retrieved from the abattoir after exsanguination.
Pancreases were flushed with UW cold storage solution and prepared surgically, then either …

234.11: Impact of Hypothermic Oxygenated PErfusion (HOPE) During Hypothermic Preservation and Normothermic Reperfusion in a Preclinical Porcine Model of …

B Mesnard, T Prudhomme, E Ogbemudia… - …, 2022 - journals.lww.com
Purpose: The proportion of pancreatic transplants from standard criteria donors (SCD) is
decreasing with a parallel increase in the number of extended criteria donors (ECD) and of …

Development of ex vivo normothermic perfusion as an innovative method to assess pancreases after preservation

A Ogbemudia - Journal of the Nuffield Department of Surgical …, 2022 - journal.nds.ox.ac.uk
Objective Static cold storage (SCS) is the standard method for pancreas preservation but
does not facilitate objective organ assessment prior to transplantation. Normothermic …