Neuroprotective effects of ginsenoside Rg1 through the Wnt/β-catenin signaling pathway in both in vivo and in vitro models of Parkinson's disease

T Zhou, G Zu, X Zhang, X Wang, S Li, X Gong… - …, 2016 - Elsevier
Abstract Ginsenoside Rg1 (Rg1) is a major bioactive ingredient in Panax ginseng that has
low toxicity and has been shown to have neuroprotective effects. The objectives of the …

[HTML][HTML] Ginsenoside Rb1 confers neuroprotection via promotion of glutamate transporters in a mouse model of Parkinson's disease

YL Zhang, Y Liu, XP Kang, CY Dou, RG Zhuo… - …, 2018 - Elsevier
Ginsenoside Rb1 has been demonstrated to protect dopaminergic (DA) neurons from death
in vitro. However, the neuroprotective effects and underlying mechanism of Rb1 in treating …

Rg1 improves LPS-induced Parkinsonian symptoms in mice via inhibition of NF-κB signaling and modulation of M1/M2 polarization

J Liu, M Zhao, Z Zhang, L Cui, X Zhou… - Acta Pharmacologica …, 2020 - nature.com
Ginsenoside Rg1 is one of the most active ingredients in ginseng, which has been reported
to protect dopaminergic neurons and improve behavioral defects in MPTP model, 6-OHDA …

A Preclinical Systematic Review of Ginsenoside‐Rg1 in Experimental Parkinson's Disease

L Song, MB Xu, XL Zhou, D Zhang… - Oxidative Medicine …, 2017 - Wiley Online Library
To date, no drug has been proven to be neuroprotective or disease‐modifying for
Parkinson's disease (PD) in clinical trials. Here, we aimed to assess preclinical evidence of …

Potential neuroprotective activity of Ginseng in Parkinson's disease: a review

E González-Burgos, C Fernandez-Moriano… - Journal of Neuroimmune …, 2015 - Springer
Parkinson's disease is a chronic, multifactorial and progressive neurologic condition that
affects around six million people worldwide, normally over 60 years of age, and is …

Ginsenoside Rg1 exerts neuroprotective effects in 3-nitropronpionic acid-induced mouse model of Huntington's disease via suppressing MAPKs and NF-κB pathways …

X Yang, S Chu, Z Wang, F Li, Y Yuan… - Acta Pharmacologica …, 2021 - nature.com
Huntington's disease (HD) is one of main neurodegenerative diseases, characterized by
striatal atrophy, involuntary movements, and motor incoordination. Ginsenoside Rg1 (Rg1) …

Ginsenoside Rg3 exerts a neuroprotective effect in rotenone-induced Parkinson's disease mice via its anti-oxidative properties

Y Han, T Wang, C Li, Z Wang, Y Zhao, J He, L Fu… - European journal of …, 2021 - Elsevier
Abstract Ginsenoside Rg3, extracted from Panax ginseng CA Meyer, has been shown to
possess neuroprotective properties. The present study aims to investigate the …

[HTML][HTML] Multitarget effects of Korean red ginseng in animal model of Parkinson's disease: antiapoptosis, antioxidant, antiinflammation, and maintenance of blood …

JH Choi, M Jang, SY Nah, S Oh, IH Cho - Journal of ginseng research, 2018 - Elsevier
Background Ginsenosides are the main ingredients of Korean Red Ginseng. They have
extensively been studied for their beneficial value in neurodegenerative diseases such as …

Ginsenoside Rg1 attenuates dopamine-induced apoptosis in PC12 cells by suppressing oxidative stress

XC Chen, YG Zhu, LA Zhu, C Huang, Y Chen… - European Journal of …, 2003 - Elsevier
In Parkinson's disease, neuroprotective therapy to rescue dopamine neurons has been
proposed. Ginsenoside Rg1, one of the biologically active ingredients of ginseng, may be a …

Immunomodulatory and neuroprotective effects of ginsenoside Rg1 in the MPTP (1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine)-induced mouse model of Parkinson's …

T Zhou, G Zu, X Wang, X Zhang, S Li, Z Liang… - International …, 2015 - Elsevier
Ginsenoside Rg1, one of the biologically active ingredients of ginseng, has been considered
to be a candidate neuroprotective drug. The objective of the study was to study the protective …