Antibody secreting plasma cell plays an indispensable role in humoral immunity. As
activated B cell undergoes germinal center reaction and develops into plasma cell, it …

Plasma cell differentiation requires silencing of B cell transcription, while it establishes
antibody-secretory function and long-term survival. The transcription factors Blimp-1 and …

The transcription factor Blimp-1 is necessary for the generation of plasma cells. Here we
studied its functions in plasmablast differentiation by identifying regulated Blimp-1 target …

Abstract Blimp-1, a transcriptional repressor, drives the terminal differentiation of B cells to
plasma cells. Using DNA microarrays, we found that introduction of Blimp-1 into B cells …

The activated B-cell (ABC) to plasmablast transition encompasses the cusp of antibody-
secreting cell (ASC) differentiation. We explore this transition with integrated analysis in …

Multiple myeloma (MM) is a malignancy of plasma cells (PC) that grow within the bone
marrow and maintain massive immunoglobulin (Ig) production. Disease evolution is driven …

The differentiation of B cells into immunoglobulin-secreting plasma cells is controlled by two
transcription factors, Blimp-1 and XBP1. By gene expression profiling, we defined a set of …

B‐cell progenitor fate determinant interferon regulatory factor 4 (IRF4) exerts key roles in the
pathogenesis and progression of multiple myeloma (MM), a currently incurable plasma cell …

Background Multiple myeloma (MM), characterized by cancerous proliferation of
plasmablasts (PB) and plasma cells (PC), remains incurable in many patients. Differentially …

Plasma cell differentiation involves coordinated changes in gene expression and functional
properties of B cells. Here, we study the role of Mzb1, a Grp94 cochaperone that is …