Spatially-resolved profiling of tissue monosaccharides not only gives an insight into the
spatial heterogeneity of monosaccharides, but also helps to decipher the possible roles of …

Carbohydrates play crucial regulatory roles in various physiological and pathological
processes. However, the low ionization efficiency and the presence of linkage pattern …

Mass spectrometry imaging (MSI) is a powerful technique for investigating the biomolecular
locations within tissues. However, the isomeric compounds are rarely distinguished due to …

Carbohydrates play critically important roles in energy supply and biological functions in
living systems. However, it has been a great challenge to identify saccharides and …

Analysis of oligosaccharides with matrix-assisted laser desorption/ionization mass
spectrometry (MALDI-MS) remains challenging due to their low ionization efficiency. The …

Sensitive analysis of oligosaccharides by matrix-assisted laser desorption/ionization time-of-
flight mass spectrometry (MALDI-TOF MS) is significantly hampered by the low ionization …

Monosaccharides play important roles in biological processes. Sensitive and accurate
analyses of monosaccharides remain challenging because of their high hydrophilicities and …

Aberrant glycosylation is associated with most of the diseases. Direct imaging and profiling
of N-glycans on tissue sections can reveal tissue-specific and/or disease-associated N …

Glycosylation is a major protein post-translational modification whose dysregulation has
been associated with many diseases. Herein, an on-tissue chemical derivatization strategy …

Quantification of oligosaccharides is of great importance to investigate variations or changes
in the glycans of glycoconjugates. Mass spectrometry (MS) has been widely applied to …