Indiscriminate use of antibiotics globally has lead to an increase in emergence of drug-
resistant pathogens under both nosocomial, as well as more worryingly, in community …

Infectious diseases are one of the most important and urgent health problems in the world.
According to the World Health Organization (WHO) statistics, infectious and parasitic …

Background: Multiple strategies have been recommended for prevention and control of
antibacterial resistance. Solutions will need to be found soon if we are not to run the serious …

In this study, a structure-activity relationship (SAR) compound series based on the NDH-2
inhibitor diphenyleneiodonium (DPI) was synthesised. Compounds were evaluated primarily …

Occurrence of antibacterial and antimycobacterial resistance stimulated a thrust to discover
new drugs for infectious diseases. Herein we report the work on re-engineering nalidixic …

In recent times, many researchers in pharmaceutical chemistry have been preoccupied with
the quest for new potent anti-infective agents to combat Antimicrobial resistance. A novel …

Antimicrobial resistance is a global challenge and the effectiveness of old antibiotics is
decreasing. Discovery and development of antibacterial agents have been accelerated to …

Antimicrobial resistance is a global threat, leading to an alarming increase in the prevalence
of bacterial infections that can no longer be treated with available antibiotics. The World …

Constructing a new antibacterial structural framework is an effective strategy to combat drug
resistance. This work discovered a class of naphthalimidopropanediols (NIOLs) as a novel …

New treatments for tuberculosis infection are critical to combat the emergence of multidrug-
and extensively drug-resistant Mycobacterium tuberculosis (Mtb). We report the …