[HTML][HTML] Targeting the PDGF signaling pathway in tumor treatment
CH Heldin - Cell Communication and Signaling, 2013 - Springer
Platelet-derived growth factor (PDGF) isoforms and PDGF receptors have important
functions in the regulation of growth and survival of certain cell types during embryonal …
functions in the regulation of growth and survival of certain cell types during embryonal …
Autocrine PDGF stimulation in malignancies
CH Heldin - Upsala journal of medical sciences, 2012 - Taylor & Francis
Platelet-derived growth factor (PDGF) isoforms are important mitogens for different types of
mesenchymal cells, which have important functions during the embryonal development and …
mesenchymal cells, which have important functions during the embryonal development and …
Platelet-derived growth factor receptors: a therapeutic target in solid tumors
D George - Seminars in oncology, 2001 - Elsevier
Platelet-derived growth factor (PDGF) was one of the first polypeptide growth factors
identified that signals through a cell surface tyrosine kinase receptor (PDGF-R) to stimulate …
identified that signals through a cell surface tyrosine kinase receptor (PDGF-R) to stimulate …
PDGF receptors as targets in tumor treatment
A Östman, CH Heldin - Advances in cancer research, 2007 - Elsevier
Signaling through platelet‐derived growth factor (PDGF) receptors contributes to multiple
tumor‐associated processes. The recent introduction of clinically useful PDGF inhibitors …
tumor‐associated processes. The recent introduction of clinically useful PDGF inhibitors …
[HTML][HTML] PDGF receptors as cancer drug targets
Ever since the discovery 20 years ago that the transforming retroviral v-sis oncogene is
derived from the platelet-derived growth factor (PDGF) B chain gene, PDGF signaling has …
derived from the platelet-derived growth factor (PDGF) B chain gene, PDGF signaling has …
PDGF receptors-mediators of autocrine tumor growth and regulators of tumor vasculature and stroma
A Östman - Cytokine & growth factor reviews, 2004 - Elsevier
PDGFs and their cognate tyrosine kinase α-and β-receptors are involved in multiple tumor-
associated processes including autocrine growth stimulation of tumor cells, stimulation of …
associated processes including autocrine growth stimulation of tumor cells, stimulation of …
Involvement of platelet‐derived growth factor ligands and receptors in tumorigenesis
CH Heldin, J Lennartsson… - Journal of internal …, 2018 - Wiley Online Library
Platelet‐derived growth factor (PDGF) isoforms and their receptors have important roles
during embryogenesis, particularly in the development of various mesenchymal cell types in …
during embryogenesis, particularly in the development of various mesenchymal cell types in …
PDGF receptor kinase inhibitors for the treatment of PDGF driven diseases
A Levitzki - Cytokine & growth factor reviews, 2004 - Elsevier
PDGF and its receptors are involved in a variety of diseases: cancers, atherosclerosis,
balloon injury induced restenosis, pulmonary fibrosis and more. In all cases enhanced …
balloon injury induced restenosis, pulmonary fibrosis and more. In all cases enhanced …
PDGF and PDGF receptors in glioma
I Nazarenko, SM Hede, X He, A Hedrén… - Upsala journal of …, 2012 - Taylor & Francis
The family of platelet-derived growth factors (PDGFs) plays a number of critical roles in
normal embryonic development, cellular differentiation, and response to tissue damage. Not …
normal embryonic development, cellular differentiation, and response to tissue damage. Not …
Platelet-derived growth factor (PDGF) autocrine signaling regulates survival and mitogenic pathways in glioblastoma cells: evidence that the novel PDGF-C and PDGF …
NA Lokker, CM Sullivan, SJ Hollenbach, MA Israel… - Cancer research, 2002 - AACR
Glioblastoma multiforme, the most common form of malignant brain tumor, is resistant to all
forms of therapy and causes death within 9–12 months of diagnosis. Glioblastomas are …
forms of therapy and causes death within 9–12 months of diagnosis. Glioblastomas are …