Targeting PI3K/Akt signaling in prostate cancer therapy
M Hashemi, A Taheriazam, P Daneii… - Journal of Cell …, 2023 - Springer
Urological cancers have obtained much attention in recent years due to their mortality and
morbidity. The most common and malignant tumor of urological cancers is prostate cancer …
morbidity. The most common and malignant tumor of urological cancers is prostate cancer …
Interplay among PI3K/AKT, PTEN/FOXO and AR signaling in prostate cancer
The PI3K signaling pathway is activated in a majority of cancer types. It promotes
tumorigenesis by regulating nutrient metabolism, cell proliferation, survival, migration, and …
tumorigenesis by regulating nutrient metabolism, cell proliferation, survival, migration, and …
[PDF][PDF] The PI3K/AKT pathway in the pathogenesis of prostate cancer
H Chen, L Zhou, X Wu, R Li, J Wen… - … Biosci (Landmark Ed), 2016 - article.imrpress.com
Despite recent advances in our understanding of the biological behavior of prostate cancer
(PCa), PCa is becoming the most common malignancy in men worldwide. The …
(PCa), PCa is becoming the most common malignancy in men worldwide. The …
PI3K/PTEN/AKT signaling regulates prostate tumor angiogenesis
PI3K pathway exerts its function through its downstream molecule AKT in regulating various
cell functions including cell proliferation, cell transformation, cell apoptosis, tumor growth …
cell functions including cell proliferation, cell transformation, cell apoptosis, tumor growth …
[HTML][HTML] Targeting the PI3K/Akt pathway in prostate cancer: challenges and opportunities
P Toren, A Zoubeidi - International journal of oncology, 2014 - spandidos-publications.com
Abstract The PI3K/Akt pathway is an actively pursued therapeutic target in oncology. In
prostate cancer, the activation of this pathway appears to be characteristic of many …
prostate cancer, the activation of this pathway appears to be characteristic of many …
Activation of PI3K‐Akt signaling pathway promotes prostate cancer cell invasion
S Shukla, GT MacLennan, DJ Hartman… - … journal of cancer, 2007 - Wiley Online Library
Abstract Activated phosphoinositide 3‐kinase (PI3K) and its downstream target Akt/PKB are
important signaling molecules and key survival factors involved in the control of cell …
important signaling molecules and key survival factors involved in the control of cell …
PI3 kinase integrates Akt and MAP kinase signaling pathways in the regulation of prostate cancer
A Goc, B Al-Husein… - International …, 2011 - spandidos-publications.com
Abstract PI3 kinase (PI3K), Akt and MAP kinase (MAPK) pathways are central to many
classical signaling cascades and are often de-regulated in many cancers. Due to this …
classical signaling cascades and are often de-regulated in many cancers. Due to this …
AR signaling and the PI3K pathway in prostate cancer
Prostate cancer is a leading cause of cancer-related death in men worldwide. Aberrant
signaling in the androgen pathway is critical in the development and progression of prostate …
signaling in the androgen pathway is critical in the development and progression of prostate …
PI3K pathway in prostate cancer: All resistant roads lead to PI3K
Abstract The phosphoinositide 3-kinase (PI3K) pathway integrates multifarious
environmental cues to regulate cell survival, growth, and metabolism. Hyperactivation of the …
environmental cues to regulate cell survival, growth, and metabolism. Hyperactivation of the …
The PI3K-AKT-mTOR pathway and prostate cancer: at the crossroads of AR, MAPK, and WNT signaling
BY Shorning, MS Dass, MJ Smalley… - International journal of …, 2020 - mdpi.com
Oncogenic activation of the phosphatidylinositol-3-kinase (PI3K), protein kinase B
(PKB/AKT), and mammalian target of rapamycin (mTOR) pathway is a frequent event in …
(PKB/AKT), and mammalian target of rapamycin (mTOR) pathway is a frequent event in …