Strategies toward structural and functional 'optimization'of animal peptide toxins
N Andreotti, H Ziadi, S Mouhat, M De Waard… - International Journal of …, 2012 - ajol.info
Background: venoms of a variety of animal species (ie scorpions, snakes, spiders, sea
anemones, marine cone snails, worms, and insects) are rich sources of bioactive …
anemones, marine cone snails, worms, and insects) are rich sources of bioactive …
Structure-function strategies to improve the pharmacological value of animal toxins
M De Waard, JM Sabatier - Handbook of Biologically Active Peptides, 2006 - Elsevier
Animal venoms are rich sources of bioactive compounds that possess obvious
pharmacological, therapeutic, and/or bio technological values. A majority of these …
pharmacological, therapeutic, and/or bio technological values. A majority of these …
[HTML][HTML] Venomics in medicinal chemistry
S Dutertre - Future medicinal chemistry, 2014 - Taylor & Francis
To the general public, venomous animals often evoke repulsion or even uncontrollable fear,
yet they also fascinate by their almost mystical dimension. For researchers, however, they …
yet they also fascinate by their almost mystical dimension. For researchers, however, they …
[HTML][HTML] Animal toxins and their advantages in biotechnology and pharmacology
Biodiversity provides a huge source of new chemical entities that could be useful for the
development of new therapies. An example is venomous animals, which produce venoms …
development of new therapies. An example is venomous animals, which produce venoms …
Snake-and spider-venom-derived toxins as lead compounds for drug development
P Lazarovici - Snake and Spider Toxins: Methods and Protocols, 2020 - Springer
Snake and spider venoms have been developed by nature as a defense mechanism against
predators or to immobilize their prey by blocking the cardiovascular, respiratory, and/or …
predators or to immobilize their prey by blocking the cardiovascular, respiratory, and/or …
[HTML][HTML] Toxins in drug discovery and pharmacology
S Peigneur, J Tytgat - Toxins, 2018 - mdpi.com
Venoms from marine and terrestrial animals (cone snails, scorpions, spiders, snakes,
centipedes, cnidarian, etc.) can be seen as an untapped cocktail of biologically active …
centipedes, cnidarian, etc.) can be seen as an untapped cocktail of biologically active …
[HTML][HTML] Peptides from animal venom and poisons
AN de Oliveira, AM Soares, SL da Silva - International Journal of Peptide …, 2023 - Springer
International Journal of Peptide Research and Therapeutics technologies, functional genetic
information can be determined (Banshidhar et al. 2023). This information is translated in the …
information can be determined (Banshidhar et al. 2023). This information is translated in the …
Venoms as a platform for human drugs: translating toxins into therapeutics
GF King - Expert opinion on biological therapy, 2011 - Taylor & Francis
Introduction: An extraordinarily diverse range of animals have evolved venoms for predation,
defence, or competitor deterrence. The major components of most venoms are peptides and …
defence, or competitor deterrence. The major components of most venoms are peptides and …
Progress and challenges in the optimization of toxin peptides for development as pain therapeutics
C Netirojjanakul, LP Miranda - Current Opinion in Chemical Biology, 2017 - Elsevier
Highlights•More than ten toxin derived peptides have entered clinical study for pain.•Major
targets for pain therapeutics include Na V s, Ca V s, and ASICs.•Selectivity and target …
targets for pain therapeutics include Na V s, Ca V s, and ASICs.•Selectivity and target …