Consumption of the putative chemopreventive agent curcumin by cancer patients: assessment of curcumin levels in the colorectum and their pharmacodynamic …
Curcumin, a constituent of the spice turmeric, has been shown to reduce the adenoma
burden in rodent models of colorectal cancer accompanied by a reduction of levels of the …
burden in rodent models of colorectal cancer accompanied by a reduction of levels of the …
Prolonged biologically active colonic tissue levels of curcumin achieved after oral administration—a clinical pilot study including assessment of patient acceptability
GRB Irving, LM Howells, S Sale, I Kralj-Hans… - Cancer prevention …, 2013 - AACR
Curcumin, the main constituent of turmeric, is suspected to possess cancer chemopreventive
properties. Pharmacokinetic and pharmacodynamic parameters have been reported, but few …
properties. Pharmacokinetic and pharmacodynamic parameters have been reported, but few …
Curcumin for chemoprevention of colon cancer
JJ Johnson, H Mukhtar - Cancer letters, 2007 - Elsevier
The most practical approach to reduce the morbidity and mortality of cancer is to delay the
process of carcinogenesis through the use of chemopreventive agents. This necessitates …
process of carcinogenesis through the use of chemopreventive agents. This necessitates …
Phase IIa clinical trial of curcumin for the prevention of colorectal neoplasia
RE Carroll, RV Benya, DK Turgeon, S Vareed… - Cancer prevention …, 2011 - AACR
Curcumin is derived from the spice tumeric and has antiinflammatory and antineoplastic
effects in vitro and in animal models, including preventing aberrant crypt foci (ACF) and …
effects in vitro and in animal models, including preventing aberrant crypt foci (ACF) and …
Dose escalation of a curcuminoid formulation
CD Lao, MT Ruffin, D Normolle, DD Heath… - … and alternative medicine, 2006 - Springer
Background Curcumin is the major yellow pigment extracted from turmeric, a commonly-
used spice in India and Southeast Asia that has broad anticarcinogenic and cancer …
used spice in India and Southeast Asia that has broad anticarcinogenic and cancer …
Metabolism of the cancer chemopreventive agent curcumin in human and rat intestine
CR Ireson, DJL Jones, S Orr, MWH Coughtrie… - … Biomarkers & Prevention, 2002 - AACR
Curcumin, the yellow pigment in turmeric, prevents malignancies in the intestinal tract of
rodents. It is under clinical evaluation as a potential colon cancer chemopreventive agent …
rodents. It is under clinical evaluation as a potential colon cancer chemopreventive agent …
Pharmacodynamic and Pharmacokinetic Study of Oral Curcuma Extract in Patients with Colorectal Cancer
RA Sharma, HR McLelland, KA Hill, CR Ireson… - Clinical Cancer …, 2001 - AACR
Curcuma spp. extracts, particularly the dietary polyphenol curcumin, prevent colon cancer in
rodents. In view of the sparse information on the pharmacodynamics and pharmacokinetics …
rodents. In view of the sparse information on the pharmacodynamics and pharmacokinetics …
Curcumin in cancer chemoprevention: molecular targets, pharmacokinetics, bioavailability, and clinical trials
Curcumin (diferuloylmethane), a derivative of turmeric is one of the most commonly used
and highly researched phytochemicals. Abundant sources provide interesting insights into …
and highly researched phytochemicals. Abundant sources provide interesting insights into …
[HTML][HTML] Anti-carcinogenic properties of curcumin on colorectal cancer
J Park, CN Conteas - World journal of gastrointestinal oncology, 2010 - ncbi.nlm.nih.gov
Curcumin has been used in traditional Indian medicine for many centuries for its anti-
inflammatory and anti-carcinogenic properties. There has been some promising research …
inflammatory and anti-carcinogenic properties. There has been some promising research …
Detection of curcumin and its metabolites in hepatic tissue and portal blood of patients following oral administration
Studies in vitro and in animal models of colorectal and hepatocellular cancers suggest that
curcumin is an effective chemopreventive agent. In this pilot trial, we investigated whether …
curcumin is an effective chemopreventive agent. In this pilot trial, we investigated whether …