Consumption of the putative chemopreventive agent curcumin by cancer patients: assessment of curcumin levels in the colorectum and their pharmacodynamic …

G Garcea, DP Berry, DJL Jones, R Singh… - … Biomarkers & Prevention, 2005 - AACR
Curcumin, a constituent of the spice turmeric, has been shown to reduce the adenoma
burden in rodent models of colorectal cancer accompanied by a reduction of levels of the …

Prolonged biologically active colonic tissue levels of curcumin achieved after oral administration—a clinical pilot study including assessment of patient acceptability

GRB Irving, LM Howells, S Sale, I Kralj-Hans… - Cancer prevention …, 2013 - AACR
Curcumin, the main constituent of turmeric, is suspected to possess cancer chemopreventive
properties. Pharmacokinetic and pharmacodynamic parameters have been reported, but few …

Curcumin for chemoprevention of colon cancer

JJ Johnson, H Mukhtar - Cancer letters, 2007 - Elsevier
The most practical approach to reduce the morbidity and mortality of cancer is to delay the
process of carcinogenesis through the use of chemopreventive agents. This necessitates …

Phase IIa clinical trial of curcumin for the prevention of colorectal neoplasia

RE Carroll, RV Benya, DK Turgeon, S Vareed… - Cancer prevention …, 2011 - AACR
Curcumin is derived from the spice tumeric and has antiinflammatory and antineoplastic
effects in vitro and in animal models, including preventing aberrant crypt foci (ACF) and …

Dose escalation of a curcuminoid formulation

CD Lao, MT Ruffin, D Normolle, DD Heath… - … and alternative medicine, 2006 - Springer
Background Curcumin is the major yellow pigment extracted from turmeric, a commonly-
used spice in India and Southeast Asia that has broad anticarcinogenic and cancer …

Metabolism of the cancer chemopreventive agent curcumin in human and rat intestine

CR Ireson, DJL Jones, S Orr, MWH Coughtrie… - … Biomarkers & Prevention, 2002 - AACR
Curcumin, the yellow pigment in turmeric, prevents malignancies in the intestinal tract of
rodents. It is under clinical evaluation as a potential colon cancer chemopreventive agent …

Pharmacodynamic and Pharmacokinetic Study of Oral Curcuma Extract in Patients with Colorectal Cancer

RA Sharma, HR McLelland, KA Hill, CR Ireson… - Clinical Cancer …, 2001 - AACR
Curcuma spp. extracts, particularly the dietary polyphenol curcumin, prevent colon cancer in
rodents. In view of the sparse information on the pharmacodynamics and pharmacokinetics …

Curcumin in cancer chemoprevention: molecular targets, pharmacokinetics, bioavailability, and clinical trials

A Shehzad, F Wahid, YS Lee - Archiv der Pharmazie, 2010 - Wiley Online Library
Curcumin (diferuloylmethane), a derivative of turmeric is one of the most commonly used
and highly researched phytochemicals. Abundant sources provide interesting insights into …

[HTML][HTML] Anti-carcinogenic properties of curcumin on colorectal cancer

J Park, CN Conteas - World journal of gastrointestinal oncology, 2010 - ncbi.nlm.nih.gov
Curcumin has been used in traditional Indian medicine for many centuries for its anti-
inflammatory and anti-carcinogenic properties. There has been some promising research …

Detection of curcumin and its metabolites in hepatic tissue and portal blood of patients following oral administration

G Garcea, DJL Jones, R Singh, AR Dennison… - British journal of …, 2004 - nature.com
Studies in vitro and in animal models of colorectal and hepatocellular cancers suggest that
curcumin is an effective chemopreventive agent. In this pilot trial, we investigated whether …