The bioactivation of drugs is often associated with toxicological outcomes; however, for most
cases, the causal relationship between bioactivation and toxicity is not well established …

The drug-metabolizing enzymes that contribute to the metabolism or bioactivation of a drug
play a crucial role in defining the absorption, distribution, metabolism, and excretion …

The P450 type cytochromes are responsible for the metabolism of a wide variety of
xenobiotics and endogenous compounds. Although P450-catalyzed reactions are generally …

Most clinically used drugs are metabolized in the body via oxidation, reduction, or hydrolysis
reactions, which are considered phase I reactions. Cytochrome P450 (P450) enzymes …

Cytochrome P450 constitute a superfamily of heme-containing enzymes that catalyze the
oxidative biotransformation of structurally diverse xenobiotics including drugs. Inhibition of …

Background: Cytochrome monooxygenases P450 enzymes (CYPs) are terminal oxidases,
belonging to the multi-gene family of heme-thiolate enzymes and located in multiple sites of …

Cytochrome P450 (P450) enzymes oxidize xenobiotics into chemically reactive metabolites
or intermediates as well as into stable metabolites. If the reactivity of the product is very high …

Among drugs that cause pharmacokinetic drug–drug interactions, mechanism-based
inactivators of cytochrome P450 represent several of those agents that cause interactions of …

Following the drug administration, patients are exposed not only to the parent drug itself, but
also to the metabolites generated by drug-metabolizing enzymes. The role of drug …

One of the major clinical concerns is possible drug interactions that can be the result of
abrogation of the P450 pathway (s) of metabolism causing toxicity due to elevated …