[HTML][HTML] Neuronal NR4A1 deficiency drives complement-coordinated synaptic stripping by microglia in a mouse model of lupus
X Han, T Xu, C Ding, D Wang, G Yao, H Chen… - … and Targeted Therapy, 2022 - nature.com
Neuropsychiatric lupus (NPSLE) is a frequent manifestation of systemic lupus
erythematosus (SLE) that occurs in 40–90% of SLE patients; however, the underlying …
erythematosus (SLE) that occurs in 40–90% of SLE patients; however, the underlying …
The nuclear receptor Nr4a1 acts as a microglia rheostat and serves as a therapeutic target in autoimmune-driven central nervous system inflammation
T Rothe, N Ipseiz, M Faas, S Lang… - The Journal of …, 2017 - journals.aai.org
Microglia cells fulfill key homeostatic functions and essentially contribute to host defense
within the CNS. Altered activation of microglia, in turn, has been implicated in …
within the CNS. Altered activation of microglia, in turn, has been implicated in …
[HTML][HTML] Neuropsychiatric systemic lupus erythematosus persists despite attenuation of systemic disease in MRL/lpr mice
AD Stock, J Wen, J Doerner, LC Herlitz… - Journal of …, 2015 - Springer
Background Systemic lupus erythematosus (SLE) is a prototypical autoimmune disease
marked by both B and T cell hyperactivity which commonly affects the joints, skin, kidneys …
marked by both B and T cell hyperactivity which commonly affects the joints, skin, kidneys …
[HTML][HTML] A novel microglia-specific transcriptional signature correlates with behavioral deficits in neuropsychiatric lupus
HM Makinde, DR Winter, D Procissi, EV Mike… - Frontiers in …, 2020 - frontiersin.org
Neuropsychiatric symptoms of systemic lupus erythematosus (NP-SLE) affect over one-half
of SLE patients, yet underlying mechanisms remain largely unknown. We demonstrate that …
of SLE patients, yet underlying mechanisms remain largely unknown. We demonstrate that …
Microglia activation in the presence of intact blood–brain barrier and disruption of hippocampal neurogenesis via IL-6 and IL-18 mediate early diffuse neuropsychiatric …
Introduction Inflammatory mediators are detected in the cerebrospinal fluid of systemic lupus
erythematosus patients with central nervous system involvement (NPSLE), yet the …
erythematosus patients with central nervous system involvement (NPSLE), yet the …
[HTML][HTML] B cell and/or autoantibody deficiency do not prevent neuropsychiatric disease in murine systemic lupus erythematosus
J Wen, J Doerner, S Chalmers, A Stock, H Wang… - Journal of …, 2016 - Springer
Background Neuropsychiatric lupus (NPSLE) can be one of the earliest clinical
manifestations in human lupus. However, its mechanisms are not fully understood. In lupus …
manifestations in human lupus. However, its mechanisms are not fully understood. In lupus …
[HTML][HTML] Microglial NLRP3 inflammasome activation upon TLR2 and TLR5 ligation by distinct α-synuclein assemblies
H Scheiblich, L Bousset, S Schwartz… - The Journal of …, 2021 - journals.aai.org
Parkinson's disease (PD) is the second most common age-related neurodegenerative
disorder and is characterized by the formation of cellular inclusions inside neurons that are …
disorder and is characterized by the formation of cellular inclusions inside neurons that are …
Microglia-dependent synapse loss in type I interferon-mediated lupus
AR Bialas, J Presumey, A Das, CE van der Poel… - Nature, 2017 - nature.com
Systemic lupus erythematosus (SLE) is an incurable autoimmune disease characterized by
autoantibody deposition in tissues such as kidney, skin and lungs. Notably, up to 75% of …
autoantibody deposition in tissues such as kidney, skin and lungs. Notably, up to 75% of …
Lipocalin-2 is a pathogenic determinant and biomarker of neuropsychiatric lupus
EV Mike, HM Makinde, M Gulinello, K Vanarsa… - Journal of …, 2019 - Elsevier
Neuropsychiatric manifestations in lupus (NPSLE) affect∼ 20–40% of patients. In the central
nervous system, lipocalin-2 (LCN2) can promote injury through mechanisms directly linked …
nervous system, lipocalin-2 (LCN2) can promote injury through mechanisms directly linked …
CSF-1R inhibition attenuates renal and neuropsychiatric disease in murine lupus
SA Chalmers, J Wen, J Shum, J Doerner, L Herlitz… - Clinical …, 2017 - Elsevier
Systemic lupus erythematosus (SLE) is a multifactorial autoimmune disease that can affect
multiple end organs. Kidney and brain are two of the organs most commonly involved in …
multiple end organs. Kidney and brain are two of the organs most commonly involved in …