PTGER3 knockdown inhibits the vulnerability of triple‐negative breast cancer to ferroptosis

S Wang, Y Zhang, D Zhang, J Meng, N Che… - Cancer …, 2024 - Wiley Online Library
Abstract Prostaglandin E receptor 3 (PTGER3) is involved in a variety of biological
processes in the human body and is closely associated with the development and …

Identification of TFR2 as a novel ferroptosis‑related gene that serves an important role in prognosis and progression of triple‑negative breast cancer

Y Yang, J Du, YF Huang, W He, L Liu… - Oncology …, 2023 - spandidos-publications.com
Effective targeted therapeutic strategies for triple-negative breast cancer (TNBC), the most
malignant subtype of breast cancer, are currently lacking. Ferroptosis has been reported to …

PGRMC1 promotes triple-negative breast cancer cell growth via suppressing ferroptosis

Y Zhao, X Ruan, J Cheng, X Xu, M Gu, AO Mueck - Climacteric, 2023 - Taylor & Francis
Objective Triple-negative breast cancer (TNBC) is the most malignant form of breast cancer
with increasing incidence and mortality worldwide. The progesterone receptor membrane …

POU2F2-mediated Upregulation of lncRNA PTPRG-AS1 Inhibits Ferroptosis in Breast Cancer Via miR-376c-3p/SLC7A11 Axis

J Li, PT Li, W Wu, BN Ding, YG Wen, HL Cai, SX Liu… - …, 2024 - Taylor & Francis
Background: Triple-negative breast cancer (TNBC) is a subtype of BC with high rates of
mortality. The mechanism of PTPRG-AS1 in ferroptosis of TNBC was investigated. Methods …

Identification of a small molecule as inducer of ferroptosis and apoptosis through ubiquitination of GPX4 in triple negative breast cancer cells

Y Ding, X Chen, C Liu, W Ge, Q Wang, X Hao… - Journal of hematology & …, 2021 - Springer
Background TNBC is the most aggressive breast cancer with higher recurrence and
mortality rate than other types of breast cancer. There is an urgent need for identification of …

Ferroptosis as a promising targeted therapy for triple negative breast cancer

K Mokhtarpour, S Razi, N Rezaei - Breast Cancer Research and …, 2024 - Springer
Purpose Triple negative breast cancer (TNBC) is a challenging subtype characterized by the
absence of estrogen receptor (ER), progesterone receptor (PR), and human epidermal …

Mutant p53 protects triple-negative breast adenocarcinomas from ferroptosis in vivo

D Dibra, S Xiong, SM Moyer, AK El-Naggar, Y Qi… - Science …, 2024 - science.org
The TP53 tumor suppressor gene is mutated early in most of the patients with triple-negative
breast cancer (TNBC). The most frequent TP53 alterations are missense mutations that …

[HTML][HTML] Ferroptosis heterogeneity in triple-negative breast cancer reveals an innovative immunotherapy combination strategy

F Yang, Y Xiao, JH Ding, X Jin, D Ma, DQ Li, JX Shi… - Cell metabolism, 2023 - cell.com
Treatment of triple-negative breast cancer (TNBC) remains challenging. Deciphering the
orchestration of metabolic pathways in regulating ferroptosis will provide new insights into …

Role of GPX4-mediated ferroptosis in the sensitivity of triple negative breast cancer cells to gefitinib

X Song, X Wang, Z Liu, Z Yu - Frontiers in oncology, 2020 - frontiersin.org
Gefitinib resistance in triple negative breast cancer (TNBC) is a growing important concern.
Glutathione peroxidase 4 (GPX4) is a main regulator of ferroptosis, which is pivotal for TNBC …

Ferroptosis: the emerging player in remodeling triple-negative breast cancer

J Li, D He, S Li, J Xiao, Z Zhu - Frontiers in Immunology, 2023 - frontiersin.org
Triple-negative breast cancer (TNBC) is a highly heterogeneous breast tumor type that is
highly malignant, invasive, and highly recurrent. Ferroptosis is a unique mode of …