Motor dysfunction as an intermediate phenotype across schizophrenia and other psychotic disorders: progress and perspectives

D Hirjak, KM Kubera, PA Thomann, RC Wolf - Schizophrenia research, 2018 - Elsevier
Primary motor abnormalities (PMA), as found in patients with schizophrenia, are
quantitatively and qualitatively distinct markers of motor system abnormalities. PMA have …

Motor dysfunction within the schizophrenia-spectrum: a dimensional step towards an underappreciated domain

D Hirjak, PA Thomann, KM Kubera, ND Wolf… - Schizophrenia …, 2015 - Elsevier
At the beginning of the 20th century, genuine motor abnormalities (GMA) were considered to
be intricately linked to schizophrenia. Subsequently, however, GMA have been increasingly …

Motor system pathology in psychosis

S Walther, VA Mittal - Current psychiatry reports, 2017 - Springer
Abstract Purpose of Review Motor abnormalities are an intrinsic feature of psychosis.
Neurological soft signs, Parkinsonism, dyskinesia, and other motor phenomena are …

Psychomotor symptoms of schizophrenia map on the cerebral motor circuit

S Walther - Psychiatry Research: Neuroimaging, 2015 - Elsevier
Schizophrenia is a devastating disorder thought to result mainly from cerebral pathology.
Neuroimaging studies have provided a wealth of findings of brain dysfunction in …

Motor dysfunction and sensorimotor cortex activation changes in schizophrenia: a study with functional magnetic resonance imaging

J Schröder, M Essig, K Baudendistel, T Jahn, I Gerdsen… - Neuroimage, 1999 - Elsevier
Recent studies demonstrate a diminished activation of the sensorimotor cortex and
supplementary motor area (SMA) in schizophrenia which may be involved in the …

Supplementary motor area (SMA) volume is associated with psychotic aberrant motor behaviour of patients with schizophrenia

K Stegmayer, H Horn, A Federspiel, N Razavi… - Psychiatry Research …, 2014 - Elsevier
We aimed to investigate whether aberrant motor behavior in schizophrenia was associated
with structural alterations in the motor system. Whole brain voxel based morphometry of …

[HTML][HTML] Beyond boundaries: in search of an integrative view on motor symptoms in schizophrenia

M Morrens, L Docx, S Walther - Frontiers in psychiatry, 2014 - frontiersin.org
Schizophrenia is typically conceived as an illness characterized by positive, negative, and
cognitive symptoms. However, most schizophrenia patients also display a wide range of …

Motor dysfunction as research domain in the period preceding manifest schizophrenia: a systematic review

D Hirjak, A Meyer-Lindenberg, KM Kubera… - Neuroscience & …, 2018 - Elsevier
Schizophrenia is a severe behavioral syndrome of neurodevelopmental nature marked by
primary or genuine motor abnormalities (GMA), which refer to spontaneous and medication …

Altered cortico-basal ganglia motor pathways reflect reduced volitional motor activity in schizophrenia

T Bracht, S Schnell, A Federspiel, N Razavi… - Schizophrenia …, 2013 - Elsevier
Little is known about the neurobiology of hypokinesia in schizophrenia. Therefore, the aim of
this study was to investigate alterations of white matter motor pathways in schizophrenia and …

Relationship of neuromotor disturbances to psychosis symptoms in first-episode neuroleptic-naive schizophrenia patients

L Cortese, MP Caligiuri, AK Malla, R Manchanda… - Schizophrenia …, 2005 - Elsevier
From the very inception of the modern diagnostic scheme for psychotic disorders,
abnormalities in motor function have been observed in these conditions. Despite …