There is a considerable interest in the modification of existing antibiotics to generate new
antimicrobials. Glycopeptide antibiotics (GPAs) are effective against serious Gram-positive …

We show that two α-N-methyltransferases involved in the biosynthesis of glycopeptide
antibiotics (GPAs) already recognise partly crosslinked precursor peptides of teicoplanin …

Gentamicins are heavily methylated, clinically valuable pseudotrisaccharide antibiotics
produced by Micromonospora echinospora. GenN has been characterized as an S …

Background: The glycopeptide antibiotics vancomycin and teicoplanin are currently the last
line of defence against some microorganisms that are resistant to many drugs. The …

Glycopeptide antibiotics such as vancomycin and teicoplanin are biosynthesised by
actinomycetes [1] and have been called the drugs of “last resort” because they are often …

During the biosynthesis of the vancomycin-class antibiotic chloroeremomycin, TDP-epi-
vancosaminyltransferase GtfA catalyzes the attachment of 4-epi-vancosamine from a TDP …

The glycopeptide antibiotics vancomycin and teicoplanin are vital components of modern
anti-infective chemotherapy exhibiting outstanding activity against Gram-positive pathogens …

The glycopeptides vancomycin and teicoplanin are clinically important antibiotics. The
carbohydrate portions of these molecules affect biological activity, and there is great interest …

The glycopeptide antibiotics are an important class of natural products biosynthesised by the
actinomycetes. The prevalence of methicillin-resistant Staphylococcus aureus (MRSA)[1] …

The 2, 3, 6-trideoxysugar l-epivancosamine is the terminal sugar added to the aglycone
scaffold in chloroeremomycin, a member of the vancomycin family of glycopeptide …