Sir2 (silent information regulator 2) is an NAD+-dependent histone deacetylase that
contributes to longevity in yeast. SIRT1, a mammalian Sir2 ortholog, deacetylates histones …

The human NAD+-dependent protein deacetylase SIRT2 resides predominantly in the
cytoplasm where it functions as a tubulin deacetylase. Here we report that SIRT2 maintains …

Sir2 is an NAD-dependent histone deacetylase that functions in longevity, gene silencing,
heterochromatin formation, DNA repair, and suppression of DNA recombination in yeast …

The Saccharomyces cerevisiae Sir2 protein is an NAD+-dependent histone deacetylase that
plays a critical role in transcriptional silencing, genome stability, and longevity. A human …

Members of the evolutionarily conserved silent information regulator 2 (Sir2) protein family
are nicotinamide adenine dinucleotide (NAD+)-dependent histone deacetylases. In yeast …

Background SIR2 is an NAD+-dependent deacetylase–implicated in the regulation of
lifespan in species as diverse as yeast, worms, and flies. We previously reported that the …

We characterized human SirT1, one of the human homologs of the budding yeast Sir2p, an
NAD+-dependent histone deacetylase involved in establishing repressive chromatin and …

Under the condition of ADP-ribosylation reaction in vitro, NAD concentration is
approximately a few micromolar and the deacetylase activity of Sir2 is not detectable (Imai et …

The yeast Sir2 (silent information regulator-2) protein functions as an NAD+-dependent
histone deacetylase to silence gene expression from the mating-type locus, tolomeres and …

The yeast Sir2 protein mediates chromatin silencing through an intrinsic NAD‐dependent
histone deacetylase activity. Sir2 is a conserved protein and was recently shown to regulate …