Autoantibody-associated congenital heart block: outcome in mothers and children

J Waltuck, JP Buyon - Annals of internal medicine, 1994 - acpjournals.org
Objective: To determine the initial clinical status and the long-term outcome of mothers and
their children with autoantibody-associated congenital heart block. Design: Dynamic …

Autoimmune-associated congenital heart block: demographics, mortality, morbidity and recurrence rates obtained from a national neonatal lupus registry

JP Buyon, R Hiebert, J Copel, J Craft… - Journal of the American …, 1998 - jacc.org
Objectives. The present study describes the demographics, mortality, morbidity and
recurrence rates of autoimmune-associated congenital heart block (CHB) using information …

Autoimmune associated congenital heart block: integration of clinical and research clues in the management of the maternal/foetal dyad at risk

JP Buyon, RM Clancy… - Journal of internal …, 2009 - Wiley Online Library
One of the strongest associations with autoantibodies directed to components of the SSA/Ro‐
SSB/La ribonucleoprotein complex is the development of congenital heart block (CHB) in an …

Isolated congenital heart block. long‐term outcome of mothers and characterization of the immune response to ss‐a/ro and to ss‐b/la

H Julkunen, P Kurki, R Kaaja, R Heikkilä… - … : Official Journal of …, 1993 - Wiley Online Library
Objective. To study the long-term outcome of mothers of children with isolated congenital
heart block (CHB) and to characterize the maternal autoantibody response to SS-A/Ro and …

Long-term outcome of mothers of children with complete congenital heart block

J Press, Y Uziel, RM Laxer, L Luy, RM Hamilton… - The American journal of …, 1996 - Elsevier
OBJECTIVES: To determine the health of mothers of offspring with complete congenital
heart block (CHB) both at the time of delivery of the affected child and in the long-term, and …

[HTML][HTML] Neonatal lupus syndromes

CE Tseng, JP Buyon - Rheumatic Disease Clinics of North America, 1997 - Elsevier
Nearly a century ago, Morquio first described the rare defect of isolated congenital heart
block (CHB). 86 In 1928, Aylward reported the occurrence of CHB in two children whose …

Epidemiology, etiology, detection, and treatment of autoantibody-associated congenital heart block in neonatal lupus

DM Friedman, A Rupel, JP Buyon - Current rheumatology reports, 2007 - Springer
Neonatal lupus syndrome is a model of passively acquired autoimmunity in which the
pregnant woman's serum contains specific antibodies to 52 or 60 kd SSA/Ro and/or 48 kd …

Anti-SSA/Ro and anti-SSB/La antibody-mediated congenital heart block

N Costedoat-Chalumeau, S Georgin-Lavialle… - Lupus, 2005 - journals.sagepub.com
When anti-SSA/Ro antibodies are present in sera of mothers with connective tissue
diseases, the incidence of congenital heart block (CHB) has been reported to be 1-2% in …

Description of 214 cases of autoimmune congenital heart block: results of the French neonatal lupus syndrome

K Levesque, N Morel, A Maltret, G Baron… - Autoimmunity …, 2015 - Elsevier
Background Cardiac neonatal lupus syndrome is due to anti-SSA or SSB antibodies and
mainly includes congenital heart block (CHB) and dilated cardiomyopathy (DCM). Its optimal …

Evaluation of fetuses in a study of intravenous immunoglobulin as preventive therapy for congenital heart block: Results of a multicenter, prospective, open‐label …

DM Friedman, C Llanos, PM Izmirly… - Arthritis & …, 2010 - Wiley Online Library
Objective The recurrence rate of anti‐SSA/Ro–associated congenital heart block (CHB) is
17%. Sustained reversal of third‐degree block has never been achieved. Based on potential …