Anecdotal evidence surrounding Tibetans' and Sherpas' exceptional tolerance to hypobaric
hypoxia has been recorded since the beginning of high-altitude exploration. These …

Between 1960 and 2003, 13 Chinese expeditions successfully reached the summit of
Chomolungma (Mt Everest or Sagarmatha). Forty-five of the 80 summiteers were Tibetan …

The Himalayan Sherpas, a human population of Tibetan descent, are highly adapted to life
in the hypobaric hypoxia of high altitude. Mechanisms involving enhanced tissue oxygen …

At high altitude, hypobaric hypoxia is a significant stress for humans and other animals,
challenging oxygen homeostasis and therefore tissue metabolism. Genetic signals of …

Wu, Tianyi, and Bengt Kayser. High altitude adaptation in Tibetans. High Alt. Med. Biol. 7:
193–208, 2006.—Since the beginning of the Himalayan climbing era, the anecdotal …

The Tibetan Plateau is one of the highest regions on Earth. Tibetan highlanders are adapted
to life and reproduction in a hypoxic environment and possess a suite of distinctive …

Highland natives show unique breathing patterns and ventilatory responses at altitude, both
at rest and during exercise. For many ventilatory traits, there is also significant variation …

High-altitude environments provide natural experimental settings to investigate adaptation to
environmental stress. An important evolutionary and functional question is whether sea-level …

Abstract Simonson, Tatum S. Altitude adaptation: A glimpse through various lenses. High Alt
Med Biol 16: 125–137, 2015.—Recent availability of genome-wide data from highland …

Objectives This report presents a perspective on the broad research trends in the biology of
human populations at high‐altitude and their contributions to the improved understanding of …