Any independent life requires iron to survive. Whereas iron deficiency causes oxygen
insufficiency, excess iron is a risk for cancer, generating a double-edged sword. Iron …

Cells require iron for essential functions like energy production and signaling. However, iron
can also engage in free radical formation and promote cell proliferation thereby contributing …

Nuclear receptor coactivator 4 mediated ferritinophagy is an autophagic phenomenon that
specifically involves ferritin to release intracellular free iron. Ferritinophagy is implicated in …

Ferroptosis is a form of regulated cell death modality associated with disturbed iron-
homeostasis and unrestricted lipid peroxidation. Ample evidence has depicted an essential …

An important micronutrient, iron is used by the cell either as an ion or upon assembly into
heme or ironsulfur cluster (ISC) cofactors. Iron is generally not a free ion in the body, but is …

Iron is essential for almost all organisms, being involved in oxygen transport, DNA synthesis,
and respiration; however, it is also potentially toxic via the formation of free radicals. Thus …

Iron is an essential nutrient to life. However, the ability of iron to cycle between the oxidized
and reduced forms contributes to the formation of reactive oxygen species. The generation …

Ferritinophagy, a form of autophagy, is also an important part of ferroptosis, a type of
regulated cell death resulting from abnormal iron metabolism involving the production of …

Iron is an ancient, essential and versatile transition metal found in almost all living
organisms on Earth. This fundamental trace element is used in the synthesis of heme and …

Background Ferroptosis, a newly form of regulated cell death (RCD), is characterized by iron
dyshomeostasis and unrestricted lipid peroxidation. Emerging evidence depicts a pivotal …