Neisseria meningitidis (meningococcus) is an important cause of meningitis and sepsis.
Currently, there is no effective vaccine against serogroup B meningococcal infection. Host …

Almost all invasive Neisseria meningitidis isolates express capsular polysaccharide. Ab is
required for complement-dependent killing of meningococci. Although alternative pathway …

Neisseria gonorrhoeae and Neisseria meningitidis have evolved intricate mechanisms to
evade complement-mediated killing. Sialylation of gonococcal lipooligosaccharide (LOS) …

Encapsulated meningococci are complement sensitive only in the presence of bactericidal
antibodies by yet-unexplored mechanisms. The objective of this study was to investigate the …

Certain complement defects are associated with an increased propensity to contract
Neisseria meningitidis infections. We performed detailed analyses of complement-mediated …

Complement is a key arm of the innate immune defenses against the pathogenic neisseriae.
We previously identified lipooligosaccharide on Neisseria meningitidis as an acceptor for …

Among 25 serogroup B Neisseria meningitidis clinical isolates, we identified four (16%) with
high factor H binding protein (FHbp) expression that were resistant to complement-mediated …

Neisseria meningitidis inhibits the alternative pathway (AP) of complement using diverse
mechanisms, including expression of capsule (select serogroups), Neisserial surface protein …

Meningococcal infection remains a worldwide health problem, and understanding the
mechanisms by which Neisseria meningitidis evades host innate and acquired immunity is …

Serogroup B meningococci express sialic acids on their surfaces as a modification of the
lipooligosaccharide (LOS) and as capsular material consisting of alpha2, 8-linked sialic acid …