[HTML][HTML] A new perspective on NAFLD: Focusing on the crosstalk between peroxisome proliferator-activated receptor alpha (PPARα) and farnesoid X receptor (FXR)

S Zhou, H You, S Qiu, D Yu, Y Bai, J He, H Cao… - Biomedicine & …, 2022 - Elsevier
Nonalcoholic fatty liver disease (NAFLD) is primarily caused by abnormal lipid metabolism
and the accumulation of triglycerides in the liver. NAFLD is also associated with hepatic …

[HTML][HTML] Role of peroxisome proliferators-activated receptors in the pathogenesis and treatment of nonalcoholic fatty liver disease

ER Kallwitz, A McLachlan, SJ Cotler - World journal of …, 2008 - ncbi.nlm.nih.gov
Nonalcoholic fatty liver disease (NAFLD) is highly prevalent and can result in nonalcoholic
steatohepatitis (NASH) and progressive liver disease including cirrhosis and hepatocellular …

[HTML][HTML] Bile acid nuclear receptor farnesoid X receptor: therapeutic target for nonalcoholic fatty liver disease

SG Kim, BK Kim, K Kim, S Fang - Endocrinology and Metabolism, 2016 - ncbi.nlm.nih.gov
Nonalcoholic fatty liver disease (NAFLD) is one of the causes of fatty liver, occurring when
fat is accumulated in the liver without alcohol consumption. NAFLD is the most common liver …

Non‐alcoholic fatty liver disease: the bile acid‐activated farnesoid x receptor as an emerging treatment target

M Fuchs - Journal of lipids, 2012 - Wiley Online Library
Non‐alcoholic fatty liver disease (NAFLD) is currently evolving as the most common liver
disease worldwide. It may progress to liver cirrhosis and liver cancer and is poised to …

PPARs and nonalcoholic fatty liver disease

KHH Liss, BN Finck - Biochimie, 2017 - Elsevier
Nonalcoholic fatty liver disease (NAFLD) encompasses a range of liver pathology ranging
from simple steatosis to varying degrees of inflammation, hepatocyte injury and fibrosis …

Roles of PPARs in NAFLD: potential therapeutic targets

A Tailleux, K Wouters, B Staels - … et Biophysica Acta (BBA)-Molecular and …, 2012 - Elsevier
Non-alcoholic fatty liver disease (NAFLD) is a liver pathology with increasing prevalence
due to the obesity epidemic. Hence, NAFLD represents a rising threat to public health …

Nonalcoholic fatty liver disease: pathogenesis and potential for nuclear receptors as therapeutic targets

J George, C Liddle - Molecular Pharmaceutics, 2008 - ACS Publications
Nonalcoholic fatty liver disease (NAFLD) is a consequence of insulin resistance
encompassing a spectrum that extends from simple hepatic steatosis through to …

Nuclear receptor modulation for the treatment of nonalcoholic fatty liver disease

CD Fuchs, SA Traussnigg… - Seminars in liver …, 2016 - thieme-connect.com
Nuclear receptors (NRs) are ligand-activated transcriptional regulators of several key
metabolic processes including hepatic lipid and glucose metabolism, bile acid homeostasis …

[HTML][HTML] Peroxisome proliferator-activated receptors as targets to treat non-alcoholic fatty liver disease

V Souza-Mello - World journal of hepatology, 2015 - ncbi.nlm.nih.gov
Lately, the world has faced tremendous progress in the understanding of non-alcoholic fatty
liver disease (NAFLD) pathogenesis due to rising obesity rates. Peroxisome proliferator …

Peroxisome proliferator-activated receptors and their novel ligands as candidates for the treatment of non-alcoholic fatty liver disease

A Fougerat, A Montagner, N Loiseau, H Guillou… - Cells, 2020 - mdpi.com
Non-alcoholic fatty liver disease (NAFLD) is a major health issue worldwide, frequently
associated with obesity and type 2 diabetes. Steatosis is the initial stage of the disease …