DNA methylation in newborns conceived by assisted reproductive technology

SE Håberg, CM Page, Y Lee, HE Nustad… - Nature …, 2022 - nature.com
Assisted reproductive technology (ART) may affect fetal development through epigenetic
mechanisms as the timing of ART procedures coincides with the extensive epigenetic …

Assisted reproductive technologies are associated with limited epigenetic variation at birth that largely resolves by adulthood

B Novakovic, S Lewis, J Halliday, J Kennedy… - Nature …, 2019 - nature.com
More than 7 million individuals have been conceived by Assisted Reproductive
Technologies (ART) and there is clear evidence that ART is associated with a range of …

Association of medically assisted reproduction with offspring cord blood DNA methylation across cohorts

D Caramaschi, J Jungius, CM Page… - Human …, 2021 - academic.oup.com
STUDY QUESTION Is cord blood DNA methylation associated with having been conceived
by medically assisted reproduction? SUMMARY ANSWER This study does not provide …

Comparison of genome-wide and gene-specific DNA methylation between ART and naturally conceived pregnancies

N Melamed, S Choufani, LE Wilkins-Haug, G Koren… - Epigenetics, 2015 - Taylor & Francis
Data linking assisted reproductive technologies (ART) with aberrant DNA methylation is
limited and inconclusive. In addition, most studies to date have analyzed only a small …

Impact of assisted reproduction, infertility, sex and paternal factors on the placental DNA methylome

S Choufani, AL Turinsky, N Melamed… - Human molecular …, 2019 - academic.oup.com
Abstract Children conceived using Assisted Reproductive Technologies (ART) have a
higher incidence of growth and birth defects, attributable in part to epigenetic perturbations …

DNA methylation patterns within whole blood of adolescents born from assisted reproductive technology are not different from adolescents born from natural …

B Penova-Veselinovic, PE Melton… - Human …, 2021 - academic.oup.com
STUDY QUESTION Do the epigenome-wide DNA methylation profiles of adolescents born
from ART differ from the epigenome of naturally conceived counterparts? SUMMARY …

DNA methylation and gene expression changes derived from assisted reproductive technologies can be decreased by reproductive fluids

S Canovas, E Ivanova, R Romar, S García-Martínez… - Elife, 2017 - elifesciences.org
The number of children born since the origin of Assisted Reproductive Technologies (ART)
exceeds 5 million. The majority seem healthy, but a higher frequency of defects has been …

DNA methylation signatures in cord blood of ICSI children

N El Hajj, L Haertle, M Dittrich, S Denk… - Human …, 2017 - academic.oup.com
Abstract STUDY QUESTION Does ICSI induce specific DNA methylation changes in the
resulting offspring? SUMMARY ANSWER Although several thousand analyzed CpG sites …

DNA methylation in offspring conceived after assisted reproductive techniques: a systematic review and meta-analysis

R Cannarella, A Crafa, LM Mongioì, L Leggio… - Journal of clinical …, 2022 - mdpi.com
Background: In the last 40 years, assisted reproductive techniques (ARTs) have emerged as
potentially resolving procedures for couple infertility. This study aims to evaluate whether …

DNA methylation differences between in vitro- and in vivo-conceived children are associated with ART procedures rather than infertility

S Song, J Ghosh, M Mainigi, N Turan, R Weinerman… - Clinical …, 2015 - Springer
Background We, and others, have demonstrated previously that there are differences in
DNA methylation and transcript levels of a number of genes in cord blood and placenta …