Meningioma DNA methylation groups identify biological drivers and therapeutic vulnerabilities

A Choudhury, ST Magill, CD Eaton, BC Prager… - Nature …, 2022 - nature.com
Meningiomas are the most common primary intracranial tumors. There are no effective
medical therapies for meningioma patients, and new treatments have been encumbered by …

Hypermitotic meningiomas harbor DNA methylation subgroups with distinct biological and clinical features

A Choudhury, WC Chen, CHG Lucas… - Neuro …, 2023 - academic.oup.com
Background Meningiomas, the most common primary intracranial tumors, can be separated
into 3 DNA methylation groups with distinct biological drivers, clinical outcomes, and …

Mutational patterns and regulatory networks in epigenetic subgroups of meningioma

N Paramasivam, D Hübschmann, UH Toprak… - Acta …, 2019 - Springer
DNA methylation patterns delineate clinically relevant subgroups of meningioma. We
previously established the six meningioma methylation classes (MC) benign 1–3 …

Global epigenetic profiling identifies methylation subgroups associated with recurrence-free survival in meningioma

A Olar, KM Wani, CD Wilson, G Zadeh, F DeMonte… - Acta …, 2017 - Springer
Meningioma is the most common primary brain tumor and carries a substantial risk of local
recurrence. Methylation profiles of meningioma and their clinical implications are not well …

Advances in meningioma genetics: novel therapeutic opportunities

M Preusser, PK Brastianos, C Mawrin - Nature Reviews Neurology, 2018 - nature.com
Meningiomas currently are among the most frequent intracranial tumours. Although the
majority of meningiomas can be cured by surgical resection,∼ 20% of patients have an …

DNA methylation-based classification and grading system for meningioma: a multicentre, retrospective analysis

F Sahm, D Schrimpf, D Stichel, DTW Jones… - The lancet …, 2017 - thelancet.com
Background The WHO classification of brain tumours describes 15 subtypes of meningioma.
Nine of these subtypes are allotted to WHO grade I, and three each to grade II and grade III …

Prognostic impact of genetic alterations and methylation classes in meningioma

AS Berghoff, T Hielscher, G Ricken, J Furtner… - Brain …, 2022 - Wiley Online Library
Meningiomas are classified based on histological features, but genetic and epigenetic
features are emerging as relevant biomarkers for outcome prediction and may supplement …

Integrated molecular-morphologic meningioma classification: a multicenter retrospective analysis, retrospectively and prospectively validated

SLN Maas, D Stichel, T Hielscher, P Sievers… - Journal of clinical …, 2021 - ascopubs.org
PURPOSE Meningiomas are the most frequent primary intracranial tumors. Patient outcome
varies widely from benign to highly aggressive, ultimately fatal courses. Reliable …

Multiple approaches converge on three biological subtypes of meningioma and extract new insights from published studies

JC Bayley, CC Hadley, AO Harmanci, AS Harmanci… - Science …, 2022 - science.org
One-fifth of meningiomas classified as benign by World Health Organization (WHO)
histopathological grading will behave malignantly. To better diagnose these tumors, several …

Epigenetic subclassification of meningiomas based on genome-wide DNA methylation analyses

Y Kishida, A Natsume, Y Kondo, I Takeuchi… - …, 2012 - academic.oup.com
Meningiomas are among the most common intracranial tumors and are mostly curable by
surgical resection. However, some populations of meningiomas with benign histological …