Down‐regulating lncRNA KCNQ1OT1 relieves type II alveolar epithelial cell apoptosis during one‐lung ventilation via modulating miR‐129‐5p/HMGB1 axis induced …

Z Song, Z Wang, J Cai, Y Zhou, Y Jiang… - Environmental …, 2024 - Wiley Online Library
Objective Endothelial glycocalyx (EG) maintains vascular homeostasis and is destroyed
after one‐lung ventilation (OLV)‐induced lung injury. Long noncoding RNAs (lncRNAs) are …

LncRNA SNHG6 accelerates hyperoxia-induced lung cell injury via regulating miR-335 to activate KLF5/NF-κB pathway

YN Meng, YP Chen, M Yang, ZH An, YC Deng - Cytokine, 2022 - Elsevier
Background Bronchopulmonary dysplasia (BPD) is a common chronic lung disease in
premature infants, and its pathogenesis has not been clarified. Long non-coding RNAs …

Long non-coding RNA CDKN2B-AS1 enhances LPS-induced apoptotic and inflammatory damages in human lung epithelial cells via regulating the miR-140-5p …

B Wang, Q Sun, W Ye, L Li, P Jin - BMC Pulmonary Medicine, 2021 - Springer
Background Sepsis is a complicated disease with systemic inflammation or organ
dysfunction, and it is the leading cause of acute lung injury (ALI). Long non-coding RNAs …

Vascular endothelial glycocalyx shedding in ventilator-induced lung injury in rats

D Ou, W Xu, Z Feng, Y Yang, W Xue, Q Zhang, X Li… - Microvascular …, 2024 - Elsevier
Endothelial permeability deterioration is involved in ventilator-induced lung injury (VILI). The
integrality of vascular endothelial glycocalyx (EG) is closely associated with endothelial …

rhKGF-2 Attenuates Smoke Inhalation Lung Injury of Rats via Activating PI3K/Akt/Nrf2 and Repressing FoxO1-NLRP3 Inflammasome

Z Fu, Z Jiang, G Guo, X Liao, M Liu… - Frontiers in …, 2021 - frontiersin.org
Smoke inhalation injury is an acute pathological change caused by thermal stimulation or
toxic substance absorption through respiratory epithelial cells. This study aims to probe the …

Knockdown of lncRNA MALAT1 alleviates LPS-induced acute lung injury via inhibiting apoptosis through the miR-194-5p/FOXP2 axis

C Nan, N Zhang, KCP Cheung, H Zhang… - Frontiers in cell and …, 2020 - frontiersin.org
Purpose We aimed to identify and verify the key genes and lncRNAs associated with acute
lung injury (ALI) and explore the pathogenesis of ALI. Research showed that lower …

Gpnmb silencing protects against hyperoxia-induced acute lung injury by inhibition of mitochondrial-mediated apoptosis

X Wang, S Qin, Y Ren, B Feng, J Liu… - Human & …, 2024 - journals.sagepub.com
Background: Hyperoxia-induced acute lung injury (HALI) is a complication to ventilation in
patients with respiratory failure, which can lead to acute inflammatory lung injury and chronic …

Long non-coding RNA CASC2 improved acute lung injury by regulating miR-144-3p/AQP1 axis to reduce lung epithelial cell apoptosis

H Li, H Shi, M Gao, N Ma, R Sun - Cell & Bioscience, 2018 - Springer
Background and objective Apoptosis of lung epithelial cell is implicated in the pathogenesis
of acute lung injury (ALI). To study the protective effect and mechanism of cancer …

Tanreqing Injection Attenuates Macrophage Activation and the Inflammatory Response via the lncRNA-SNHG1/HMGB1 Axis in Lipopolysaccharide-Induced Acute …

C Hu, J Li, Y Tan, Y Liu, C Bai, J Gao, S Zhao… - Frontiers in …, 2022 - frontiersin.org
The etiology of acute lung injury (ALI) is not clear, and the treatment of ALI presents a great
challenge. This study aimed to investigate the pathogenesis and potential therapeutic …

Long noncoding RNA Kcnq1ot1 prompts lipopolysaccharide-induced acute lung injury by microRNA-7a-5p/Rtn3 axis

S Yang, F Liu, D Wang - European Journal of Medical Research, 2022 - Springer
Abstract Background Long noncoding RNA (lncRNA)-regulated mechanism in acute lung
injury (ALI) has attracted special interests in study researches. We planned to disclose …