The battle against bacterial resistance to antibiotics is currently being lost. The present
analysis suggests the importance of epigenetics in the evolution of bacterial resistance …

Background The evolution of antibiotic resistance in bacteria is a topic of major medical
importance. Evolution is the result of natural selection acting on variant phenotypes. Both the …

Antibiotic resistance is conferred through a large pool of genes, which is now referred to as
the resistome. The appearance of the ever-changing structure of a cistron in the …

The persistent emergence of antibiotic resistance in bacterial populations poses a
formidable challenge to global healthcare systems. Understanding the mechanisms and …

Bacteria have an enormous genetic plasticity and adaptive potential that enables them
toinhabit almost every ecological niche on this planet and respond to drastic environmental …

Antibiotic resistance is one of the few examples of evolution that can be addressed
experimentally. The present review analyses this resistance, focusing on the networks that …

The rampant use of antibiotics in animal husbandry, farming and clinical disease treatment
has led to a significant issue with pathogen resistance worldwide over the past decades …

Adaptive antibiotic resistance is a transient metabolic adaptation of bacteria limiting their
sensitivity to low, progressively increased, concentrations of antibiotics. Unlike innate and …

Bacterial evolution of antibiotic resistance frequently has deleterious side effects on
microbial growth, virulence, and susceptibility to other antimicrobial agents. However, it is …

Bacteria clearly benefit from the possession of an antibiotic resistance gene when the
corresponding antibiotic is present. But do resistant bacteria suffer a cost of resistance (ie, a …