Bridging the gap between gut microbiota and Alzheimer's disease: a metaproteomic approach for biomarker discovery in transgenic mice

E Ayan, H DeMirci, MA Serdar, F Palermo… - International Journal of …, 2023 - mdpi.com
Alzheimer's Disease (AD) is a progressively debilitating form of dementia that affects millions
of individuals worldwide. Although a vast amount of research has investigated the complex …

The potential of the gut microbiome for identifying Alzheimer's disease diagnostic biomarkers and future therapies

Y Zhan, M Al-Nusaif, C Ding, L Zhao… - Frontiers in …, 2023 - frontiersin.org
Being isolated from the peripheral system by the blood–brain barrier, the brain has long
been considered a completely impervious tissue. However, recent findings show that the gut …

[HTML][HTML] Correlation between the gut microbiome and neurodegenerative diseases: a review of metagenomics evidence

X Liu, Y Liu, J Liu, H Zhang, C Shan… - Neural Regeneration …, 2024 - journals.lww.com
A growing body of evidence suggests that the gut microbiota contributes to the development
of neurodegenerative diseases via the microbiota-gut-brain axis. As a contributing factor …

The microbiota-gut-brain axis in health and disease and its implications for translational research

MA Schächtle, SP Rosshart - Frontiers in cellular neuroscience, 2021 - frontiersin.org
Over the past decades, microbiome research has evolved rapidly and became a hot topic in
basic, preclinical and clinical research, for the pharmaceutical industry and for the general …

Gut microbiome and Mycobiome alterations in an in vivo model of Alzheimer's disease

V D'Argenio, I Veneruso, C Gong, V Cecarini, L Bonfili… - Genes, 2022 - mdpi.com
Gut microbiota has emerged as an important key regulator of health and disease status.
Indeed, gut microbial dysbiosis has been identified in an increasing number of diseases …

[HTML][HTML] Systematic characterization of multi-omics landscape between gut microbial metabolites and GPCRome in Alzheimer's disease

Y Qiu, Y Hou, D Gohel, Y Zhou, J Xu, M Bykova… - Cell Reports, 2024 - cell.com
Shifts in the magnitude and nature of gut microbial metabolites have been implicated in
Alzheimer's disease (AD), but the host receptors that sense and respond to these …

Comparative metagenomics and metabolomes reveals abnormal metabolism activity is associated with gut microbiota in Alzheimer's disease mice

P Sun, H Zhu, X Li, W Shi, Y Guo, X Du… - International Journal of …, 2022 - mdpi.com
A common symptom in Alzheimer's disease (AD) is cognitive decline, of which the potential
pathogenesis remains unclear. In order to understand the mechanism of gut microbiota in …

Associations between gut microbiota and Alzheimer's disease: current evidences and future therapeutic and diagnostic perspectives

L Shen, HF Ji - Journal of Alzheimer's Disease, 2019 - content.iospress.com
Developing novel agents for unexplored targets to combat Alzheimer's disease (AD)
represents an urgent task due to its increasing prevalence worldwide. The present paper …

[HTML][HTML] Association of gut microbiota composition and function with a senescence-accelerated mouse model of Alzheimer's Disease using 16S rRNA gene and …

W Peng, P Yi, J Yang, P Xu, Y Wang, Z Zhang… - Aging (Albany …, 2018 - ncbi.nlm.nih.gov
Although an intriguing potential association of the gut microbiome with Alzheimer's disease
(AD) has attracted recent interest, few studies have directly assessed this relationship or …

Deciphering the intricate linkage between the gut microbiota and Alzheimer's disease: Elucidating mechanistic pathways promising therapeutic strategies

J Liang, Y Wang, B Liu, X Dong, W Cai… - CNS Neuroscience …, 2024 - Wiley Online Library
Background The gut microbiome is composed of various microorganisms such as bacteria,
fungi, and protozoa, and constitutes an important part of the human gut. Its composition is …