Summary Objective/Method Aggrecanase activity, most notably ADAMTS-5, is implicated in
pathogenic cartilage degradation. Selective monoclonal antibodies (mAbs) to both ADAMTS …

Summary Objective ADAMTS5 (aggrecanase-2) has been demonstrated to be crucial in the
development of osteoarthritis (OA), by use of several mouse mutants carrying either …

The extracellular matrix of articular cartilage is structurally specialized for efficient absorption
of mechanical impact. In particular, giant aggregates of the large chondroitin sulfate …

Osteoarthritis (OA) is a progressive disease of the joints characterized by degradation of
articular cartilage. Although disease initiation may be multi‐factorial, the cartilage …

Objective To determine the role of the proteinase ADAMTS‐1 in normal and accelerated
catabolism of aggrecan in articular and growth plate cartilage of mice. Methods Expression …

Objective Recent published studies have shown that cartilage from ADAMTS‐5–knockout
mice, but not ADAMTS‐4–or ADAMTS‐1–knockout mice, is significantly protected from …

Objective A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS5) is a
key enzyme in degradation of cartilage in osteoarthritis (OA). We report the pharmacological …

Objective To determine the importance of the enzymatic activity of ADAMTS‐4 in normal
growth and development and to evaluate the role of ADAMTS‐4 in the progression of …

There are currently no approved disease-modifying osteoarthritis (OA) drugs (DMOADs).
The aggrecanase ADAMTS-5 is key in the degradation of human aggrecan (AGC), a …

From the time of their discovery in 1999, the aggrecanases, and ADAMTS-5 in particular,
have been heavily investigated as targets for disease-modifying osteoarthritis drug …