X-ray crystallography is a critical tool in the study of biological systems. It is able to provide
information that has been a prerequisite to understanding the fundamentals of life. It is also a …

Macromolecular X-ray crystallography is routinely applied to understand biological
processes at a molecular level. However, significant time and effort are still required to solve …

Significant time and effort are often required to solve and complete a macromolecular crystal
structure. The development of automated computational methods for the analysis, solution …

Abstract The CCP4 (Collaborative Computational Project, number 4) aims to provide first a
state-of-the-art suite consisting of a collection of programs plus associated data and …

Structural genomics seeks to expand rapidly the number of protein structures in order to
extract the maximum amount of information from genomic sequence databases. The advent …

The EMBL-Hamburg Automated Crystal Structure Determination Platform is a system that
combines a number of existing macromolecular crystallographic computer programs and …

Advances in our understanding of macromolecular structure come from experimental
methods, such as X-ray crystallography, and also computational analysis of the growing …

The CCP4 (Collaborative Computational Project, Number 4) software suite for
macromolecular structure determination by X-ray crystallography groups brings together …

The advent of structural genomics initiatives has led to a pressing need for high-throughput
macromolecular structure determination. To accomplish this, new methods and inevitably …

Diffraction (X-ray, neutron and electron) and electron cryo-microscopy are powerful methods
to determine three-dimensional macromolecular structures, which are required to …