DURING the initial phase of their development, sensory neurons of the dorsal root ganglion
(DRG) require target-derived trophic support for their survival1–3, but as they mature they …

DURING vertebrate development, neuronal survival depends on target-derived neurotrophic
factors1, 2. Brain-derived neurotrophic factor3 (BDNF), a member of the neurotrophin family …

CURRENT ideas about the dependence of neurons on target-derived growth factors were
formulated on the basis of experiments involving neurons with projections to the periphery1 …

Brain-derived neurotrophic factor (BDNF), present in minute amounts in the adult central
nervous system1, is a member of the nerve growth factor (NGF)(ref. 2) family, which includes …

Primary sensory neurones in cranial and dorsal root ganglia (DRG) of adult animals are
generally thought to be maintained through connections with their peripheral (but not …

Developing vertebrate neurons are thought to depend for their survival on specific
neurotrophic proteins present in their target fields1. The limited availability of these proteins …

NEUROTROPHINS play important roles in neuronal survival during vertebrate
development1–3. Neurotrophin-4 (NT4), alone or in combination with brain-derived …

DURING normal development of the vertebrate nervous system, large numbers of neurons
in the central and peripheral nervous system undergo naturally occurring cell death1. For …

The role of neurotrophins as target-derived proteins that promote neuron survival following
their retrograde transport from the terminals to the cell bodies of neurons has been firmly …

Cultured embryonic cortical neurons from rats were used to explore mechanisms of activity-
dependent neuronal survival. Cell survival was increased by the activation of voltage …