Two members of the NF-κB (nuclear factor κB)/Rel transcription factor family, NF-κB1 and NF-
κB2, are produced as precursor proteins, NF-κB1 p105 and NF-κB2 p100 respectively …

The mammalian Rel/NF-κB family of transcription factors, including RelA, c-Rel, RelB, NF-
κB1 (p50 and its precursor p105), and NF-κB2 (p52 and its precursor p100), plays a central …

One of the primary physiological roles of nuclear factor-kappa B (NF-κB) is in the immune
system. In particular, NF-κB family members control the transcription of cytokines and …

NF-κB was first discovered and characterized 25 years ago as a key regulator of inducible
gene expression in the immune system. Thus, it is not surprising that the clearest biological …

The transcription factor NF-κB is a critical regulator of many cellular processes including cell
survival and inflammation. NF-κB functions as a hetero-or homo-dimer which can be formed …

While the classical pathway of NF-κB activation plays critical roles in a wide range of
biological processes, the more recently described “non-canonical” NF-κB pathway has …

NF-κB (nuclear factor-κB) transcription factors have multiple critical roles in the regulation of
immune responses. In unstimulated cells, NF-κB proteins are sequestered in the cytoplasm …

NF-κB was first described as a B-cell-specific transcription factor that binds the κB site in the
Ig κ light chain enhancer. Soon after, NF-κB activity was found to be inducible in all cell types …

Proteolytic degradation of the C-terminal region of NF-κB precursors to their active DNA
binding forms represents an important regulatory step in the activation of NF-κB. NF-κB2 …

In the 20 years since its discovery, research into the NF-κB (nuclear factor-κB) family of
transcription factors has revealed an amazing diversity of functions. NF-κB proteins are …