Altered pronociceptive and antinociceptive mechanisms are often implicated in painful
conditions and have been increasingly studied over the past decade. For some painful …

Low back pain (LBP) has been inconsistently associated with enhanced pronociceptive and
impaired antinociceptive mechanisms. It remains unknown whether alterations are causal …

Background People with chronic pain may exhibit pro-nociceptive phenotypes characterised
partly by reduced conditioned pain modulation (CPM). Characterising variability in CPM in …

Facilitated pain mechanisms and impaired pain inhibition are often found in chronic pain
patients. This study compared clinical pain profiles, pain sensitivity, as well as …

Background Biopsychosocial factors above and beyond pathoanatomical changes likely
contribute to the severity of chronic low back pain. A pro-nociceptive endogenous pain …

Objectives: We therefore hypothesized a differential amygdala-PAG functional connectivity
(FC) in patients with chronic LBP that is modulated by the degree of pain-related fear …

Quantitative sensory testing is widely used in human research to investigate the state of the
peripheral and central nervous system contributions in pain processing. It is a valuable tool …

Objective: The purpose of this narrative review is to analyze the available literature
concerning central sensitization and altered central pain processing in patients with chronic …

Objective. Research on chronic low back pain (cLBP) has focused heavily on structural
abnormalities with emphasis on diagnostic imaging. However, for many cLBP patients …

Objective The objective of this cross-sectional study was to analyze the relationship between
symptoms of central sensitization (CS) and important cognitive behavioral and psychosocial …