Cytoplasmic accumulation of TDP-43 in motor neurons is the most prominent pathological
feature in amyotrophic lateral sclerosis (ALS). A feedback cycle between nucleocytoplasmic …

Cytoplasmic accumulation of TDP-43 in motor neurons is the most prominent pathological
feature in amyotrophic lateral sclerosis (ALS). A feedback cycle between nucleocytoplasmic …

Nuclear exclusion of TAR DNA binding protein 43 (TDP-43) and formation of cytosolic
aggregates are a pathological characteristic of amyotrophic lateral sclerosis (ALS) …

Alterations in the glial function of TDP-43 are becoming increasingly associated with the
neurological symptoms observed in Amyotrophic Lateral Sclerosis (ALS), however, the …

Amyotrophic lateral sclerosis (ALS) is a fatal motor neuron degenerative disease. ALS-
affected motor neurons exhibit aberrant localization of a nuclear RNA binding protein, TDP …

Mislocalization and abnormal deposition of TDP-43 into the cytoplasm (TDP-43
proteinopathy) is a hallmark in neurons of amyotrophic lateral sclerosis (ALS) and …

Amyotrophic lateral sclerosis is a fatal neurodegenerative disease without a cure to reverse
its progression. Its main hallmark is the nuclear protein TDP-43, which undergoes different …

Transactive response DNA-binding protein 43 (TDP-43) is a predominantly nuclear,
ubiquitously expressed RNA and DNA-binding protein. It recognizes and binds to UG …

TDP-43-mediated proteinopathy is a key factor in the pathology of amyotrophic lateral
sclerosis (ALS). A potential underlying mechanism is dysregulation of the cytoskeleton. Here …

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease specifically affecting
cortical and spinal motor neurons. Cytoplasmic inclusions containing hyperphosphorylated …