Directed cell migration is critical for embryogenesis and organ development, wound healing
and the immune response. Microtubules are dynamic polymers that control directional …

Migration is a polarized cellular process that opposes a protrusive front edge to a retracting
trailing edge. From the front to the rear, actin-mediated forces sequentially promote cell …

Microtubules have long been implicated in the polarization of migrating cells, but how they
carry out this role is unclear. Here, we propose that microtubules determine cell polarity by …

Microtubules define the architecture and internal organization of cells by positioning
organelles and activities, as well as by supporting cell shape and mechanics. One of the …

Although microtubules have long been implicated in cell locomotion, the mechanism of their
involvement remains controversial. Most studies have concluded that microtubules play a …

Cell adhesion to the extracellular matrix is essential for cellular processes, such as migration
and invasion. In response to cues from the microenvironment, integrin-mediated adhesions …

Crosstalk between the actin cytoskeleton and microtubules promotes symmetry break to
polarize cells for division, shape changes, and migration. These cellular events are crucial …

Directional cell migration is a fundamental process in all organisms that is stringently
regulated during tissue development, chemotaxis and wound healing. Migrating cells have a …

Microtubules are core components of the cytoskeleton and serve as tracks for motor protein–
based intracellular transport. Microtubule networks are highly diverse across different cell …

Microtubules are cytoskeletal elements known as drivers of directed cell migration, vesicle
and organelle trafficking, and mitosis. In this review, we discuss new research in the lens …