Plasma cytokines are biomarkers of disease extent and mycobacterial burden in pulmonary
tuberculosis (PTB). Whether chemokines can perform the same role in PTB is not known. We …

Background Plasma chemokines are biomarkers of greater disease severity, higher
bacterial burden, and delayed sputum culture conversion in pulmonary tuberculosis (PTB) …

Background Leucocyte activating chemokines such as CCL2, CCL3, and CXCL8 together
with proinflammatory IFNγ, TNFα and downmodulatory IL10 play a central role in the …

The systemic changes in immune mediators such as cytokine and chemokines, and their
synchronized interaction that regulates the cell trafficking during Mycobacterium tuberculosis …

Cytokines are involved in the mediation and regulation of immunity, inflammation, and
haematopoiesis. Secretion patterns may reflect the pathology or etiology of different …

In this study, we explored the local cytokine/chemokine profiles in patients with active
pulmonary or pleural tuberculosis (TB) using multiplex protein analysis of bronchoalveolar …

Current diagnostic tests for tuberculosis (TB) remain limited in their ability to discriminate
between active TB (ATB) and latent TB infection (LTBI). Early clearance (EC) of TB by …

Mycobacterium tuberculosis (Mtb) infects about one-third of the world's population, with a
majority of infected individuals exhibiting latent asymptomatic infection, while 5–10% of …

Protection against Mycobacterium tuberculosis infection is dependent on T cell and
macrophage activation regulated by cytokines. Cytokines and chemokines produced at …

Interferon gamma release assays (IGRAs) have been widely used to diagnose
Mycobacterium tuberculosis (MTB) infection. However, IGRAs cannot discriminate between …