The molecular signature of tissue resident memory CD8 T cells isolated from the brain
LM Wakim, A Woodward-Davis, R Liu, Y Hu… - The Journal of …, 2012 - journals.aai.org
Tissue resident memory (Trm) CD8 T cells represent a newly described memory T cell
population. We have previously characterized a population of Trm cells that persists within …
population. We have previously characterized a population of Trm cells that persists within …
Tissue-resident memory T cells populate the human brain
J Smolders, KM Heutinck, NL Fransen… - Nature …, 2018 - nature.com
Most tissues are populated by tissue-resident memory T cells (TRM cells), which are
adapted to their niche and appear to be indispensable for local protection against …
adapted to their niche and appear to be indispensable for local protection against …
CD4+ memory T cells at home in the tissue: mechanisms for health and disease
D Schreiner, CG King - Frontiers in immunology, 2018 - frontiersin.org
During the last 10 years, a population of clonally expanded T cells that take up permanent
residence in non-lymphoid tissues has been identified. The localization of these tissue …
residence in non-lymphoid tissues has been identified. The localization of these tissue …
The precursors of CD8+ tissue resident memory T cells: from lymphoid organs to infected tissues
L Kok, D Masopust, TN Schumacher - Nature Reviews Immunology, 2022 - nature.com
CD8+ tissue resident memory T cells (TRM cells) are essential for immune defence against
pathogens and malignancies, and the molecular processes that lead to TRM cell formation …
pathogens and malignancies, and the molecular processes that lead to TRM cell formation …
Memory T cells persisting within the brain after local infection show functional adaptations to their tissue of residence
LM Wakim, A Woodward-Davis… - Proceedings of the …, 2010 - National Acad Sciences
The brain is not routinely surveyed by lymphocytes and is defined as an immuno-privileged
site. However, viral infection of the brain results in the infiltration and long-term persistence …
site. However, viral infection of the brain results in the infiltration and long-term persistence …
Origins of CD4+ circulating and tissue‐resident memory T‐cells
QP Nguyen, TZ Deng, DA Witherden… - Immunology, 2019 - Wiley Online Library
In response to infection, naive CD 4+ T‐cells proliferate and differentiate into several
possible effector subsets, including conventional T helper effector cells (TH 1, TH 2, TH 17) …
possible effector subsets, including conventional T helper effector cells (TH 1, TH 2, TH 17) …
The emerging role of resident memory T cells in protective immunity and inflammatory disease
Over the past decade, it has become clear that there is an important subset of memory T
cells that resides in tissues—tissue-resident memory T (TRM) cells. There is an emerging …
cells that resides in tissues—tissue-resident memory T (TRM) cells. There is an emerging …
The repertoires of circulating human CD8+ central and effector memory T cell subsets are largely distinct
V Baron, C Bouneaud, A Cumano, A Lim, TP Arstila… - Immunity, 2003 - cell.com
Memory T cells are divided into central and effector subsets with distinct functions and
homing capabilities. We analyzed the composition and dynamics of the CD8+ T cell …
homing capabilities. We analyzed the composition and dynamics of the CD8+ T cell …
Tissue-Resident Memory CD8+ T Cells: From Phenotype to Function
DJ Topham, EC Reilly - Frontiers in immunology, 2018 - frontiersin.org
Tissue-resident memory CD8+ T cells are an important first line of defense from infection in
peripheral non-lymphoid tissues, such as the mucosal tissues of the respiratory, digestive …
peripheral non-lymphoid tissues, such as the mucosal tissues of the respiratory, digestive …
Central memory and effector memory T cell subsets: function, generation, and maintenance
The memory T cell pool functions as a dynamic repository of antigen-experienced T
lymphocytes that accumulate over the lifetime of the individual. Recent studies indicate that …
lymphocytes that accumulate over the lifetime of the individual. Recent studies indicate that …
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