Don't worry, be happy: endocannabinoids and cannabis at the intersection of stress and reward

ND Volkow, AJ Hampson… - Annual Review of …, 2017 - annualreviews.org
Cannabis enables and enhances the subjective sense of well-being by stimulating the
endocannabinoid system (ECS), which plays a key role in modulating the response to …

The endocannabinoid system as a target for novel anxiolytic drugs

S Patel, MN Hill, JF Cheer, CT Wotjak… - … & Biobehavioral Reviews, 2017 - Elsevier
The endocannabinoid (eCB) system has attracted attention for its role in various behavioral
and brain functions, and as a therapeutic target in neuropsychiatric disease states, including …

Integrating endocannabinoid signaling and cannabinoids into the biology and treatment of posttraumatic stress disorder

MN Hill, P Campolongo, R Yehuda… - …, 2018 - nature.com
Exposure to stress is an undeniable, but in most cases surmountable, part of life. However,
in certain individuals, exposure to severe or cumulative stressors can lead to an array of …

[HTML][HTML] Endocannabinoids, stress signaling, and the locus coeruleus-norepinephrine system

RR Wyrofsky, BAS Reyes, XY Zhang, S Bhatnagar… - Neurobiology of …, 2019 - Elsevier
The endocannabinoid (eCB) system has been implicated in a variety of physiological
functions due to abundant expression of its receptors and endogenous ligands in the central …

Exploiting the multifaceted effects of cannabinoids on mood to boost their therapeutic use against anxiety and depression

M Stampanoni Bassi, L Gilio, P Maffei… - Frontiers in Molecular …, 2018 - frontiersin.org
The endocannabinoid system (ECS) has been recently recognized as a prominent promoter
of the emotional homeostasis, mediating the effects of different environmental signals …

[HTML][HTML] Targeting the endocannabinoid system to treat anxiety-related disorders

N Korem, TM Zer-Aviv, E Ganon-Elazar… - Journal of basic and …, 2016 - degruyter.com
The endocannabinoid system plays an important role in the control of emotions, and its
dysregulation has been implicated in several psychiatric disorders. The most common self …

Endocannabinoids in neuroimmunology and stress

EJ Carrier, S Patel, CJ Hillard - Current Drug Targets-CNS & …, 2005 - ingentaconnect.com
Two topics are presented in this review. In the first section, we review data regarding the
effects of the endocannabinoids (eCBs) and cannabinoid receptors on neuroimmune …

Endocannabinoids, cannabinoids and the regulation of anxiety

GN Petrie, AS Nastase, RJ Aukema, MN Hill - Neuropharmacology, 2021 - Elsevier
Cannabis has been used for hundreds of years, with its ability to dampen feelings of anxiety
often reported as a primary reason for use. Only recently has the specific role cannabinoids …

Mitigation of post‐traumatic stress symptoms by Cannabis resin: A review of the clinical and neurobiological evidence

T Passie, HM Emrich, M Karst, SD Brandt… - Drug testing and …, 2012 - Wiley Online Library
It is known from clinical studies that some patients attempt to cope with the symptoms of post‐
traumatic stress disorder (PTSD) by using recreational drugs. This review presents a case …

Seeing through the smoke: human and animal studies of cannabis use and endocannabinoid signalling in corticolimbic networks

MM Silveira, JC Arnold, SR Laviolette, CJ Hillard… - Neuroscience & …, 2017 - Elsevier
Public opinion surrounding the recreational use and therapeutic potential of cannabis is
shifting. This review describes new work examining the behavioural and neural effects of …