Marfan syndrome (MFS) is a heritable connective tissue disorder caused by mutations in
FBN1, which encodes the extracellular matrix protein fibrillin-1. To investigate the …

Excessive transforming growth factor-β (TGF-β) signaling characterizes the progression of
aortic aneurysm in mouse models of Marfan syndrome, a systemic disorder of the connective …

Aortic aneurysm and dissection account for about 2% of all deaths in industrialized
countries; they are also components of several genetic diseases, including Marfan …

Marfan syndrome (MFS) is a heritable connective tissue disorder caused by mutations in the
gene coding for FIBRILLIN-1 (FBN1), an extracellular matrix protein. MFS is inherited as an …

Mutations in fibrillin-1 cause Marfan syndrome (MFS), the most common heritable disorder of
connective tissue. Fibrillin-1 assemblies (microfibrils and elastic fibers) represent a unique …

Objective: To delineate temporal and spatial dynamics of vascular smooth muscle cell
(SMC) transcriptomic changes during aortic aneurysm development in Marfan syndrome …

Background Marfan syndrome (MFS) is caused by mutations in the gene encoding fibrillin‐1
(FBN 1); however, the mechanisms through which fibrillin‐1 deficiency causes MFS …

The Marfan syndrome (MFS) is an autosomal dominant heritable disorder of connective
tissue with highly variable clinical manifestations including aortic dilatation and dissection …

Marfan syndrome is an autosomal dominant disease of connective tissue caused by
mutations in the fibrillin-1 encoding gene FBN1. Patients present cardiovascular, ocular and …

Marfan syndrome: from gene to therapy : Current Opinion in Pediatrics Marfan syndrome: from
gene to therapy : Current Opinion in Pediatrics Log in or Register Subscribe to journalSubscribe …