Neuropathic pain arises as a consequence of a lesion or a disease affecting the
somatosensory system. This syndrome results from maladaptive changes in injured sensory …

Because of its severity, chronicity, resistance to usual therapy and its consequences on
quality of life, neuropathic pain represents a real clinical challenge. Fundamental research …

Peripheral neuropathic pain is a severe chronic pain condition which may result from trauma
to sensory nerves in the peripheral nervous system. The spared nerve injury (SNI) model …

The mechanisms underlying neuropathic pain are not well understood, resulting in
unsatisfactory treatment outcomes for many patients. Animal models underpin much of the …

Neuropathic Pain (NP) is a painful condition which is a direct consequence of a lesion or
disease affecting the somatosensory system with symptoms like allodynia, hyperalgesia. It …

Experimental models of peripheral nerve injury have been developed to study mechanisms
of neuropathic pain in living animals. The spared nerve injury (SNI) model in rodents is a …

One of the most commonly used experimental animal models for neuropathic pain is the
chronic constriction injury (CCI) where four loose ligatures are tied around the sciatic nerve …

Chronic neuropathic pain, resulting from damage to the central or peripheral nervous
system, is a prevalent and debilitating condition, affecting 7-18% of the population1, 2 …

One of the biggest challenges for discovering more efficacious drugs for the control of
neuropathic pain has been the diversity of chronic pain states in humans. It is now …

Previously we reported that the cuff model of peripheral neuropathy, in which a 2 mm
polyethylene tube is implanted around the sciatic nerve, exhibits aspects of neuropathic pain …