Parkinson's disease (PD) is the second most common neurodegenerative disorder, leading
to the progressive decline of motor control due to the loss of dopaminergic neurons in the …

With the extension of life span in recent decades, there is an increasing burden of late-onset
neurodegenerative diseases, for which effective treatments are lacking. Neurodegenerative …

Parkinson's disease (PD) is a common neurodegenerative disorder characterized by
selective loss of dopamine neurons in the substantia nigra pars compacta of the midbrain …

Alzheimer's disease (AD) is characterized by the deposition of aggregated beta-amyloid
(Aβ), which triggers a cellular stress response called the unfolded protein response (UPR) …

PARK20, an early onset autosomal recessive parkinsonism is due to mutations in the
phosphatidylinositol-phosphatase Synaptojanin 1 (Synj1). We have recently shown that the …

A major challenge in neurobiology is the identification of the mechanisms by which protein
misfolding leads to cellular toxicity. Many neurodegenerative disorders, in which aberrant …

Higher prevalence of neurodegenerative diseases is strictly connected with progressive
aging of the world population. Interestingly, a broad range of age-related …

Protein translation and folding are tightly controlled processes in all cells, by proteostasis, an
important component of which is the unfolded protein response (UPR). During periods of …

One of the pathways of the unfolded protein response, initiated by PKR-like endoplasmic
reticulum kinase (PERK), is key to neuronal homeostasis in neurodegenerative diseases …

Parkinson's disease (PD) is a slowly progressive and complex neurodegenerative disorder.
Up to date, there are no approved drugs that could slow or reverse the neurodegenerative …