The reversible attachment of ubiquitin governs the interaction, activity and degradation of
proteins whereby the type and target of this conjugation determine the biological response …

Ubiquitination, the covalent attachment of the polypeptide ubiquitin to target proteins, is a
key posttranslational modification carried out by a set of three enzymes. They include …

Site-specific conjugation of ubiquitin onto a range of DNA repair proteins regulates their
critical functions in the DNA damage response. Biochemical and structural characterization …

Protein ubiquitination is crucial to many diverse and critical functions of cells. Although it has
been long known that conjugation of ubiquitin to proteins results in their destruction by the …

Ubiquitination pathways are widely used within eukaryotic cells. The complexity of ubiquitin
signaling gives rise to a number of problems in the study of specific pathways. One problem …

Immunoblotting is a powerful technique for the semi-quantitative analysis of ubiquitylation
events, and remains the most commonly used method to study this process due to its high …

Alterations in the protein ubiquitination can lead to the development of serious pathological
conditions and diseases and, therefore, are under extensive investigation. Here we detail …

Ubiquitylation is an essential posttranslational protein modification that is implicated in a
diverse array of cellular functions. Although cells contain eight structurally distinct types of …

Protein ubiquitination is a highly orchestrated process that controls diverse aspects of
human biology. Dysregulation of this process can lead to various disease states including …

Ubiquitination is a versatile post-translational modification (PTM), which regulates diverse
fundamental features of protein substrates, including stability, activity, and localization …