INTRODUCTION: The pharmacological assessment of the factors for gastric protection of a
test substance should involve experimental models that can determine the involvement of …

In different rat models, the antisecretory and antiulcer effects of the M1-antimuscarinics
telenzepine and pirenzepine, the nonselective antimuscarinic atropine, and the H2-blockers …

The relationship to gastric secretion of 2 types of gastric ulcer produced in pylorus-occluded
rats was evaluated. Exposure to stress for 2 hr produced a high incidence of lesions in the …

Identification of novel drug molecules requires the extensive evaluation in vitro and in vivo.
Following in vitro evaluation it is necessary to efficiently screen numerous novel molecules …

Introduction: Gastric ulcer is one of the most common gastrointestinal diseases, therefore the
constant interest for new treatments is due to adverse effects induced by current therapy …

The integrity of the gastric mucosa and its ability to secrete mucus are believed to be
essential for protection of gastric mucosa against ulceration induced by aggressive factors …

The present investigation was undertaken to suggest the involvement of free radicals in the
pathogenesis of pyloric ligation induced ulcers in rats. Lipid peroxidation product (MDA) …

We examined the validity of kissing gastric ulcers induced in rats by determining the effects
of conventional antiulcer drugs. Gastric ulcers were produced by luminal application of 60 …

A new model for measuring gastric secretory parameters in awake guinea pigs is described.
A chronic cannula was surgically implanted in the stomach of each guinea pig. The rates of …

The effects of cimetidine and ranitidine, alone or combined with sulglycotide or
carbenoxolone, and those of 16, 16-dimethyl prostaglandin E2 were investigated on …