The protein deacetylase SIRT 1 has been recognized to exert its protective effect by directly
deacetylasing histone and many other transcriptional factors including p53. However, the …

Abstract Sirtuin 1 (SIRT1) is a nicotinamide adenine dinucleotide-dependent histone
deacetylase that plays diverse physiological roles. However, little is known about the …

Numerous studies indicate that Sirtuin 1 (SIRT1), a mammalian nicotinamide adenine
dinucleotide (NAD+)-dependent histone deacetylase (HDAC), plays a crucial role in p53 …

Sirtuin 2 (SIRT2) is an NAD+-dependent protein deacetylase whose targets include histone
H4 lysine 16, p53, and α-tubulin. Because deacetylation of p53 regulates its effect on …

Human SIRT1 is an enzyme that deacetylates the p53 tumor suppressor protein and has
been suggested to modulate p53-dependent functions including DNA damage-induced cell …

Abstract Sirtuins (SIRT1-7), a class of deacetylases, play major roles in DNA damage repair,
aging, and metabolism in yeast and in mammals. SIRT7 is localized in the nucleolus. It …

Sirtuins (SIRTs), which are nicotinamide adenine dinucleotide-dependent class III histone
deacetylases, regulate cell division, survival, and senescence. Although sirtinol, a synthetic …

SIRT1 is one of seven mammalian orthologs of yeast silent information regulator 2 (Sir2),
and it functions as a nicotinamide adenine dinucleotide (NAD)-dependent deacetylase …

The mammalian Sirtuins are a family of highly conserved nicotinamide adenine dinucleotide
(NAD+)‐dependent histone deacetylase. The mammalian Sirtuins family has identified …

Sirtuins (SIRTs) belong to the nicotinamide adenine dinucleotide (NAD+)-dependent class III
histone deacetylase family. They are key regulators of cellular and physiological processes …