Regular physical activity prevents development of chronic pain and activation of central neurons

KA Sluka, JM O'Donnell, J Danielson… - Journal of applied …, 2013 - journals.physiology.org
Chronic musculoskeletal pain is a significant health problem and is associated with
increases in pain during acute physical activity. Regular physical activity is protective …

Short-duration physical activity prevents the development of activity-induced hyperalgesia through opioid and serotoninergic mechanisms

LV Lima, JM DeSantana, LA Rasmussen, KA Sluka - Pain, 2017 - journals.lww.com
Regular physical activity prevents the development of chronic muscle pain through the
modulation of central mechanisms that involve rostral ventromedial medulla (RVM). We …

[HTML][HTML] Mechanism of exercise-induced analgesia: what we can learn from physically active animals

JB Lesnak, KA Sluka - Pain Reports, 2020 - journals.lww.com
Physical activity has become a first-line treatment in rehabilitation settings for individuals
with chronic pain. However, research has only recently begun to elucidate the mechanisms …

Fatiguing exercise enhances hyperalgesia to muscle inflammation

KA Sluka, LA Rasmussen - Pain, 2010 - Elsevier
Since many people with chronic fatigue present with pain and many people with chronic
pain present with fatigue, we tested if fatigue would enhance the response to pain in male …

[HTML][HTML] Regular physical activity prevents development of chronic muscle pain through modulation of supraspinal opioid and serotonergic mechanisms

RG Brito, LA Rasmussen, KA Sluka - Pain reports, 2017 - journals.lww.com
Objectives: The purpose was to examine central inhibitory mechanisms involved in
analgesia produced by wheel running. Methods: C57/Black6 mice were given access to …

[HTML][HTML] Emerging relationships between exercise, sensory nerves, and neuropathic pain

MA Cooper, PM Kluding, DE Wright - Frontiers in neuroscience, 2016 - frontiersin.org
The utilization of physical activity as a therapeutic tool is rapidly growing in the medical
community and the role exercise may offer in the alleviation of painful disease states is an …

[HTML][HTML] Benefits of exercise intervention in reducing neuropathic pain

JL Dobson, J McMillan, L Li - Frontiers in cellular neuroscience, 2014 - frontiersin.org
Peripheral neuropathy is a widespread and potentially incapacitating pathological condition
that encompasses more than 100 different forms and manifestations of nerve damage. The …

Regular physical activity prevents chronic pain by altering resident muscle macrophage phenotype and increasing interleukin-10 in mice

A Leung, NS Gregory, LAH Allen, KA Sluka - Pain, 2016 - journals.lww.com
Regular physical activity in healthy individuals prevents development of chronic
musculoskeletal pain; however, the mechanisms underlying this exercise-induced analgesia …

Does exercise increase or decrease pain? Central mechanisms underlying these two phenomena

LV Lima, TSS Abner, KA Sluka - The Journal of physiology, 2017 - Wiley Online Library
Exercise is an integral part of the rehabilitation of patients suffering a variety of chronic
musculoskeletal conditions, such as fibromyalgia, chronic low back pain and myofascial …

How does physical activity modulate pain?

LF Law, KA Sluka - Pain, 2017 - journals.lww.com
It has become increasingly clear that physical activity has numerous beneficial health
effects. One of these effects is on the development of chronic pain. Large population studies …