Gene expression regulatory networks in Trypanosoma brucei: insights into the role of the mRNA‐binding proteome

S Lueong, C Merce, B Fischer… - Molecular …, 2016 - Wiley Online Library
Control of gene expression at the post‐transcriptional level is essential in all organisms, and
RNA‐binding proteins play critical roles from mRNA synthesis to decay. To fully understand …

A Genome-Wide Tethering Screen Reveals Novel Potential Post-Transcriptional Regulators in Trypanosoma brucei

ED Erben, A Fadda, S Lueong, JD Hoheisel… - PLoS …, 2014 - journals.plos.org
In trypanosomatids, gene expression is regulated mainly by post-transcriptional
mechanisms, which affect mRNA processing, translation and degradation. Currently, our …

[HTML][HTML] Genome-wide analysis of 3′-untranslated regions supports the existence of post-transcriptional regulons controlling gene expression in trypanosomes

JG De Gaudenzi, SJ Carmona, F Agüero, AC Frasch - PeerJ, 2013 - peerj.com
In eukaryotic cells, a group of messenger ribonucleic acids (mRNAs) encoding functionally
interrelated proteins together with the trans-acting factors that coordinately modulate their …

[HTML][HTML] Regulation of RNA binding proteins in trypanosomatid protozoan parasites

MA Romaniuk, G Cervini, A Cassola - World journal of biological …, 2016 - ncbi.nlm.nih.gov
Posttranscriptional mechanisms have a critical role in the overall outcome of gene
expression. These mechanisms are especially relevant in protozoa from the genus …

Global identification of conserved post-transcriptional regulatory programs in trypanosomatids

HS Najafabadi, Z Lu, C MacPherson… - Nucleic acids …, 2013 - academic.oup.com
While regulatory programs are extensively studied at the level of transcription, elements that
are involved in regulation of post-transcriptional processes are largely unknown, and …

The emerging role of RNA‐binding proteins in the life cycle of Trypanosoma brucei

NG Kolev, E Ullu, C Tschudi - Cellular microbiology, 2014 - Wiley Online Library
One of the key questions in understanding the biology of an organism is how to correlate
cellular fate and function with gene expression patterns. This is particularly relevant for …

Posttranscriptional control and the role of RNA‐binding proteins in gene regulation in trypanosomatid protozoan parasites

SM Fernández‐Moya… - Wiley Interdisciplinary …, 2010 - Wiley Online Library
Trypanosomatids are unicellular eukaryotes responsible for severe diseases in humans.
They exhibit a number of remarkable biological phenomena, especially at the RNA level …

Regulation of gene expression in trypanosomatids: living with polycistronic transcription

C Clayton - Open biology, 2019 - royalsocietypublishing.org
In trypanosomes, RNA polymerase II transcription is polycistronic and individual mRNAs are
excised by trans-splicing and polyadenylation. The lack of individual gene transcription …

Functionally related transcripts have common RNA motifs for specific RNA-binding proteins in trypanosomes

G Noé, JG De Gaudenzi, AC Frasch - BMC molecular biology, 2008 - Springer
Background Trypanosomes mostly control gene expression by post-transcriptional events
such as modulation of mRNA stability and translational efficiency. These mechanisms …

RNA Binding Proteins and Gene Expression Regulation in Trypanosoma cruzi

BAA Romagnoli, FB Holetz, LR Alves… - Frontiers in cellular and …, 2020 - frontiersin.org
The regulation of gene expression in trypanosomatids occurs mainly at the post-
transcriptional level. In the case of Trypanosoma cruzi, the characterization of messenger …