[HTML][HTML] Icariin-loaded hydrogel regulates bone marrow mesenchymal stem cell chondrogenic differentiation and promotes cartilage repair in osteoarthritis

Y Zhu, L Ye, X Cai, Z Li, Y Fan, F Yang - Frontiers in bioengineering …, 2022 - frontiersin.org
Intra-articular injection of mesenchymal stem cells is a potential therapeutic strategy for
cartilage protection and symptom relief for osteoarthritis (OA). However, controlling …

[HTML][HTML] Combination of mesenchymal stem cells and bioactive molecules in hydrogels for osteoarthritis treatment

P Gonzalez-Fernandez, C Rodriguez-Nogales… - European Journal of …, 2022 - Elsevier
Osteoarthritis (OA) is a chronic and inflammatory disease with no effective regenerative
treatments to date. The therapeutic potential of mesenchymal stem cells (MSCs) remains to …

[HTML][HTML] Icariin promotes stable chondrogenic differentiation of bone marrow mesenchymal stem cells in self‑assembling peptide nanofiber hydrogel scaffolds

Z Wang, K Li, H Sun, J Wang… - Molecular medicine …, 2018 - spandidos-publications.com
Icariin, a traditional Chinese medicine, has previously been demonstrated to promote
chondrogenesis of bone marrow mesenchymal stem cells (BMSCs) in traditional 2D cell …

Development of an injectable thiolated icariin functionalized collagen/hyaluronic hydrogel to promote cartilage formation in vitro and in vivo

Y Liu, J Yang, Z Luo, D Li, J Lu, Q Wang… - Journal of Materials …, 2019 - pubs.rsc.org
Development of an in situ injectable hydrogel with controlled-release of bioactive molecules
is an effective strategy to maintain chondrocyte phenotype and promote cartilage formation …

Enhanced cartilage regeneration by icariin and mesenchymal stem cell-derived extracellular vesicles combined in alginate-hyaluronic acid hydrogel

S Li, Q Yuan, M Yang, X Long, J Sun, X Yuan… - … , Biology and Medicine, 2024 - Elsevier
Objective Osteoarthritis (OA) is characterized by progressive cartilage degeneration and
absence of curative therapies. Therefore, more efficient therapies are compellingly needed …

Supramolecular injectable hyaluronate hydrogels for cartilage tissue regeneration

SH Jeong, M Kim, TY Kim, H Kim, JH Ju… - ACS Applied Bio …, 2020 - ACS Publications
Mesenchymal stem cells (MSCs) have been widely investigated to repair injured cartilage
tissues for the treatment of arthritis. Despite these great efforts, the difficulty in the …

[HTML][HTML] Icariin-loaded hydrogel with concurrent chondrogenesis and anti-inflammatory properties for promoting cartilage regeneration in a large animal model

S Xu, S Zhao, Y Jian, X Shao, D Han… - Frontiers in Cell and …, 2022 - frontiersin.org
Currently, an effective repair method that can promote satisfactory cartilage regeneration is
unavailable for cartilage damages owing to inevitable inflammatory erosion. Cartilage tissue …

[HTML][HTML] Naturally derived injectable hydrogels with ROS-scavenging property to protect transplanted stem cell bioactivity for osteoarthritic cartilage repair

H Li, D Xiang, C Gong, X Wang, L Liu - Frontiers in Bioengineering …, 2023 - frontiersin.org
Intra-articular injection of adipose mesenchymal stem cells (ADSCs) is a potential alternative
to the treatment of osteoarthritis (OA) and has aroused great interest of clinical researchers …

Osteoarthritis treated with mesenchymal stem cells on hyaluronan-based scaffold in rabbit

B Grigolo, G Lisignoli, G Desando… - … Engineering Part C …, 2009 - liebertpub.com
Objective: Osteoarthritis (OA) is a disease that limits the mobility of patients and is of
considerable economical importance. Up to now, despite the increasing number of patients …

[HTML][HTML] Cocktail of hyaluronic acid and human amniotic mesenchymal cells effectively repairs cartilage injuries in sodium iodoacetate-induced osteoarthritis rats

AT Wang, QF Zhang, NX Wang, CY Yu… - … in Bioengineering and …, 2020 - frontiersin.org
Osteoarthritis (OA) is one of the most common refractory degenerative articular cartilage
diseases. Human amniotic mesenchymal cells (hAMSCs) have emerged as a promising …