Cancer is one of the leading causes of death for people worldwide. Since the completion of
the Human Genome Project, Next-Generation Sequencing has made leaps in …

Cancer arises from the accumulation of somatic mutations and genetic alterations in cell
division checkpoints and apoptosis, this often leads to abnormal tumor proliferation. Proper …

Identifying cancer type-specific driver mutations is crucial for illuminating distinct pathologic
mechanisms across various tumors and providing opportunities of patient-specific treatment …

● Large volumes of data are generated as part of even the smallest cancer genomic
experiments. Bioinformatic methods have provided solutions for easy data storage and …

Sequencing has identified millions of somatic mutations in human cancers, but
distinguishing cancer driver genes remains a major challenge. Numerous methods have …

Background The initiation and subsequent evolution of cancer are largely driven by a
relatively small number of somatic mutations with critical functional impacts, so-called driver …

Identifying the genes and mutations that drive the emergence of tumors is a critical step to
improving our understanding of cancer and identifying new directions for disease diagnosis …

In 2003 the human genome project concluded and had characterized about 99% of the
human genome. This phenomenal achievement would go on and fuel many technological …

Identifying driver mutations in cancer is notoriously difficult. To date, recurrence of a mutation
in patients remains one of the most reliable markers of mutation driver status. However …

The significant improvements in throughput and quality of DNA sequencing technology have
revolutionized our ability to identify the genetic sequence of human cells. High-throughput …