Monitoring circulating dipeptidyl peptidase 3 (DPP3) predicts improvement of organ failure and survival in sepsis: a prospective observational multinational study
Abstract Background Dipeptidyl peptidase 3 (DPP3) is a cytosolic enzyme involved in the
degradation of various cardiovascular and endorphin mediators. High levels of circulating …
degradation of various cardiovascular and endorphin mediators. High levels of circulating …
Circulating dipeptidyl peptidase-3 at admission is associated with circulatory failure, acute kidney injury and death in severely ill burn patients
F Dépret, J Amzallag, A Pollina, L Fayolle-Pivot… - Critical care, 2020 - Springer
Abstract Background Dipeptidyl peptidase-3 (DPP3) is a metallopeptidase which cleaves
bioactive peptides, notably angiotensin II, and is involved in inflammation regulation. DPP3 …
bioactive peptides, notably angiotensin II, and is involved in inflammation regulation. DPP3 …
Pancreatic stone protein as an early biomarker predicting mortality in a prospective cohort of patients with sepsis requiring ICU management
YA Que, F Delodder, I Guessous, R Graf, M Bain… - Critical care, 2012 - Springer
Introduction Biomarkers, such as C-reactive protein [CRP] and procalcitonin [PCT], are
insufficiently sensitive or specific to stratify patients with sepsis. We investigate the …
insufficiently sensitive or specific to stratify patients with sepsis. We investigate the …
Programmed death-1 levels correlate with increased mortality, nosocomial infection and immune dysfunctions in septic shock patients
C Guignant, A Lepape, X Huang, H Kherouf, L Denis… - Critical care, 2011 - Springer
Introduction Septic shock remains a major health care problem worldwide. Sepsis-induced
immune alterations are thought to play a major role in patients' mortality and susceptibility to …
immune alterations are thought to play a major role in patients' mortality and susceptibility to …
Sepsis biomarkers in unselected patients on admission to intensive or high-dependency care
MJ Llewelyn, M Berger, M Gregory, R Ramaiah… - Critical care, 2013 - Springer
Introduction Although many sepsis biomarkers have shown promise in selected patient
groups, only C-reactive protein and procalcitonin (PCT) have entered clinical practice. The …
groups, only C-reactive protein and procalcitonin (PCT) have entered clinical practice. The …
Early elevation of plasma soluble CD14 subtype, a novel biomarker for sepsis, in a rabbit cecal ligation and puncture model
M Nakamura, T Takeuchi, K Naito, K Shirakawa… - Critical Care, 2008 - Springer
Methods We developed an ELISA using two rat monoclonal antibodies against N-terminal
and C-terminal peptide sequences of rabbit sCD14-ST, respectively, to determine sCD14-ST …
and C-terminal peptide sequences of rabbit sCD14-ST, respectively, to determine sCD14-ST …
Universal changes in biomarkers of coagulation and inflammation occur in patients with severe sepsis, regardless of causative micro-organism [ISRCTN74215569]
GT Kinasewitz, SB Yan, B Basson, P Comp, JA Russell… - Critical care, 2004 - Springer
Abstract Introduction PROWESS (Recombinant Human Activated Protein C Worldwide
Evaluation in Severe Sepsis) was a phase III, randomized, double blind, placebo controlled …
Evaluation in Severe Sepsis) was a phase III, randomized, double blind, placebo controlled …
Downregulation of protein disulfide isomerase in sepsis and its role in tumor necrosis factor-alpha release
M Zhou, A Jacob, N Ho, M Miksa, R Wu, SR Maitra… - Critical Care, 2008 - Springer
Introduction Protein disulfide isomerase (PDI) is an important factor for the protein
modification step in the post-translational event. PDI plays an essential role in cell survival …
modification step in the post-translational event. PDI plays an essential role in cell survival …
Procalcitonin and C-reactive protein levels at admission as predictors of duration of acute brain dysfunction in critically ill patients
S McGrane, TD Girard, JL Thompson, AK Shintani… - Critical care, 2011 - Springer
Introduction Non-intensive care unit (ICU) cohorts have shown an association between
inflammatory disturbances and delirium, though these relationships have not been studied …
inflammatory disturbances and delirium, though these relationships have not been studied …
Combined inhibition of complement and CD14 improved outcome in porcine polymicrobial sepsis
EW Skjeflo, C Sagatun, K Dybwik, S Aam, SH Urving… - Critical Care, 2015 - Springer
Introduction Sepsis is an exaggerated and dysfunctional immune response to infection.
Activation of innate immunity recognition systems including complement and the Toll-like …
Activation of innate immunity recognition systems including complement and the Toll-like …